Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-159-0 | CAS number: 78-93-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, a NOAEC of 5014 ppm can be considered for subchronic inhalation toxicity given that the effects noted in both sexes at 5014 ppm were limited to non specific effects including decreased body weight and increased absolute liver weights and liver to body weight ratios.
Further data from secondary source (OECD SIDS) reported, that several studies assessed the neurotoxic potential of butanone. These studies provided no evidence that butanone produced direct nervous system damage but led to the potentiation of the neurotoxicity of other chemicals such as methyl n-butyl ketone, ethyl n-butyl ketone or n-hexane.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
