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Diss Factsheets
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EC number: 248-096-5 | CAS number: 26896-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-guideline study comparable to guideline study with acceptable restrictions; 24 h occlusive application, no data on purity of test substance
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Method: other: Federal Register 38, No. 187, 27.9.1973, p 27019. Method used is similar to OECD Guideline 404 (Acute Dermal Irritation/Corrosion) with some deviations (exposure period 24 h, occlusive application, no data on test substance purity, reading times slightly different: in OECD TG 404: readings to be performed 24, 48, and 72 h after patch removal (i.e. 28, 52, and 76 h after dermal administration); here readings performed 24, 48, and 72 h after dermal application).
- GLP compliance:
- no
Test material
- Reference substance name:
- Tricyclodecanedimethanol
- EC Number:
- 248-096-5
- EC Name:
- Tricyclodecanedimethanol
- Cas Number:
- 26896-48-0
- Molecular formula:
- C12H20O2
- IUPAC Name:
- [3-(hydroxymethyl)tricyclo[5.2.1.0²,⁶]decan-8-yl]methanol
- Details on test material:
- - Name of test material (as cited in study report): TCD-Alkohol TM
- Physical state: colorless viscous liquid
- Analytical purity: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: SPF-Albino-Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 1.5 - 2 kg
- Housing: individually caged
- Diet (e.g. ad libitum): compound feeds ERKA 8300 from Robert Koch oHG, Hamm, Germany
- Water (e.g. ad libitum): yes
- Acclimation period: no dat
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): pure test substance - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- up to 48 hrs after patch removal
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: test substance was applied on surgical gaze covered with occlusive PVC sheeting. The rump of the animal was wrapped with an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 hrs
SCORING SYSTEM: Skin reactions were scored according to the table of OECD Guideline 404 (Draize).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 24 hrs after patch removal
- Remarks on result:
- other: slight erythema (grade 1) were observed only at patch removal (end of 24 h exposure period)
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal: #1, #2, #4, #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal: #2, #5
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
Any other information on results incl. tables
Effects of the undiluted test substance on intact rabbit skin:
Slight irritation (erythema grade 1, no edema) was noted in 2 of 6 animals immediately after patch removal. No skin reaction was noted 24 and 48 hrs thereafter.
Animal |
Skin reaction |
After patch removal |
||
0 hrs |
24 hrs |
48 hrs |
||
1 |
Erythema |
0 |
0 |
0 |
Edema |
0 |
0 |
0 |
|
2 |
Erythema |
1 |
0 |
0 |
Edema |
0 |
0 |
0 |
|
3 |
Erythema |
0 |
0 |
0 |
Edema |
0 |
0 |
0 |
|
4 |
Erythema |
0 |
0 |
0 |
Edema |
0 |
0 |
0 |
|
5 |
Erythema |
1 |
0 |
0 |
Edema |
0 |
0 |
0 |
|
6 |
Erythema |
0 |
0 |
0 |
Edema |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Only transient, slight erythema, but no edema, was noted in 2/6 animals after 24 hr occluded contact to intact rabbit skin. The substance was not irritating to the rabbit skin, even under worst case conditions (occlusion, 24 hr-exposure period).
- Executive summary:
In a primary dermal irritation study six Himalayan rabbits were dermally exposed to 0.5 mL of octahydro-4,7-methano-1H-indenedimethanol (TCD Alkohol DM undiluted) for 24 hours to an area of approx. 6 cm². Animals then were observed for additional 48 hours. Irritation was scored by the method of Draize.
After 24 hours occlusive exposure, only 2 of 6 animals showed slight erythema (grade 1). No edema were observed. 24 hours after patch removal, the erythema had subsided. In this study, octahydro-4,7-methano-1H-indenedimethanol (TCD Alkohol DM) is minimally irritating to the skin (Hollander/Hoechst AG, 1975b).
This dermal irritation study in the rabbit is acceptable. It complies with the OECD guideline 404 with reasonable restrictions. Deviations are rather expected to enhance the irritating effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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