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tetrakis[({bis[4-(dimethylamino)phenyl] and 4-(methylamino)phenyl} or {4-(dimethylamino)phenyl and bis[4-(methylamino)phenyl]} or {tris[4-(dimethylamino)phenyl]}methylium)]C12-(branched and/or linear)-alkyl-(4-sulfonatophenoxy)benzenesulfonate and oxybis[C12-(branched and/or linear)-alkyl-benzenesulfonate].
EC number: 700-759-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1997-01-06 to 1997-01-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The reliability is rated 1 because the study followed the standard guideline of reference (OECD 404), which describes a procedure designed to evaluate this endpoint. The results were reviewed for reliability and assessed as valid, and the study was conducted under GLP condition.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- bis(bis[4-(dimethylamino)phenyl][4-(methylamino)phenyl]methylium) bis(tris[4-(dimethylamino)phenyl]methylium) 3-(dodecan-3-yl)-4-(2-dodecyl-4-sulfonatophenoxy)benzene-1-sulfonate 3-dodecyl-4-(4-sulfonatophenoxy)benzene-1-sulfonate
- EC Number:
- 700-759-4
- Molecular formula:
- not applicable
- IUPAC Name:
- bis(bis[4-(dimethylamino)phenyl][4-(methylamino)phenyl]methylium) bis(tris[4-(dimethylamino)phenyl]methylium) 3-(dodecan-3-yl)-4-(2-dodecyl-4-sulfonatophenoxy)benzene-1-sulfonate 3-dodecyl-4-(4-sulfonatophenoxy)benzene-1-sulfonate
- Details on test material:
- - Name of test material (as cited in study report): Sepisol Fast Violet 88-1239
- Substance type: Organic salt - UVCB
- Physical state: dark violet powder with green flep colour
- Lot/batch No.: 412675
- Storage condition of test material: Room temperature, sheltered from light and heat
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage BERTHO (22120 - Yffiniac, FRANCE).
- Weight at study initiation: mean weight = 2.56 kg.
- Housing: individually housed (according the directive CEE/86/609).
- Diet: granules Energy H326 (COFNA - 37000 - Tours, France).
- Acclimation period: 5 days at least before study initiation.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- distilled
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g on shaved skin moistened with 0.25 ml of distilled water (Meram lot 43216)
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.25 mL - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 72 hrs
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: the fur of the treatment region (the dorsal area of the trunk) of each rabbit was carefully removed by shaving. The test item was applied on the shaved skin.
- Type of wrap if used: the area of exposure is covered by a 2.5 x 2.5 cm gauze. This gauze square is held in place with a "Micropore" tape of 5 x 5 cm. Then the trunk is covered by a stretchable band of 10 cm wide (type band varix) , fixed with a tape.
REMOVAL OF TEST SUBSTANCE
- Washing: dry wiping and then with a coton sightly wet with distilled water
- Time after start of exposure: 4 hours
SCORING SYSTEM: Grading of Skin Reactions displayed in the OECD 404 method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and 2
- Time point:
- other: 1, 24 and 48 hrs
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72 hrs
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1 and 24 hrs
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 48 and 72 hrs
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: #1, 2 and 3
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
Erythema Score (intact skin)
Animal N° |
1 hr |
24 hrs |
48 hrs |
72 hrs |
Mean* |
5824 |
1° |
1° |
1° |
0° |
0.7 |
5826 |
1° |
1° |
1° |
0° |
0.7 |
5827 |
1° |
1° |
0° |
0° |
0.3 |
* Mean score 24, 48 and 72 hrs after patch removal.
° purple coloration
Edema Score (intact skin)
Animal N° |
1 hr |
24 hrs |
48 hrs |
72 hrs |
Mean* |
5824 |
0 |
0 |
0 |
0 |
0 |
5826 |
0 |
0 |
0 |
0 |
0 |
5827 |
0 |
0 |
0 |
0 |
0 |
* Mean score 24, 48 and 72 hrs after patch removal.
Body weights
Animal N° |
24hrs before the beginning of the study |
End of the study (72 hrs) |
5824 |
2.660 kg |
2.620 kg |
5826 |
2.500 kg |
2.540 kg |
5827 |
2.520 kg |
2.592 kg |
MEAN |
2.560 kg |
2.584 kg |
Clinical observations
Nothing to report
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions adopted, and according to the criteria defined in the directive 67/548/EEC (and its successive amendments) Sepisol Fast Violet 881239 was found to be non-irritant for the skin of the rabbit.
- Executive summary:
The aim of the study was to assess qualitatively and quantitatively irritancy or corrosion and the delay of appearance after single skin
application of 0.5 g of test element (moistened with 25 mL of distilled water), under semi-occlusive dressing for 4 hours in 3 males rabbits. The experimental protocol was established according to the official method as defined in the OECD guideline No. 404 dated July 17th, 1992.
The skin reactions (erythema and edema) were scored at 1, 24, 48 and 72 hours after patch removal.
In all animals, a very slight erythema appeared at 1 and 24 hrs after patch removal, totally reversible with 48 to 72 hrs. No edema was recored in all aminals.
The Sepisol Fast violet 881239 was unclassified among the chemicals irritating to skin, in accordance with the directive 67/548/EEC and its successive amendments.
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