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EC number: 700-408-5 | CAS number: 103429-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 August 2007 - 21 September 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to relevant test guidelines, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidance Document 23 "Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures" (September 2000)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report includes a statement of GLP compliance signed by the Study Director, and a statement of Quality Assurance, however no GLP certificate issued by an independant authority (such as an official GLP monitoring authority) was provided.
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Sample storage conditions before analysis: Samples were not stored prior to analysis (analysed as samples taken). - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The test material was added to dilution water and stirred to dissolve. No evidence of precipitation was seen at the start or end of the test. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Daphnia Magna
- Strain: Clone A
- Source: Young daphnids produced by parents which were cultured in the Kurume Laboratory were used. Daphnids [Daphnia magna (Clone A)] originally came from the University of Sheffield (Sheffield S10 2UQ, United Kingdom).
- Age at study initiation (mean and range, SD): less than 24 hours old
- Feeding during test Not fed - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 37.0 mg/L (nominal value from most recent sample, expressed in terms of CaCO3).
- Test temperature:
- 20.1 - 20.3°C
- pH:
- 7.6 - 7.8
- Dissolved oxygen:
- 8.3 - 8.4 mg/L
- Salinity:
- Not measured
- Nominal and measured concentrations:
- 101 mg/L at the start of the test; 95.1 mg/L at the end of the test.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers
- Type (delete if not applicable): closed (covered with a lid to prevent contamination by dust, and loss of test material through evaporation / volatilization).
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Adjustment of pH: No adjustment of pH
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation was recorded at 24 hours and 48 hours of the test.
TEST CONCENTRATIONS
Single concentration used at 100 mg/L (limit test).
A preliminary test was conducted at 100 mg/L, with 5 daphnids per vessel. As no immobility was seen in the preliminary test, the main study was conducted at the 100 mg/L limit. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: No immobility was observed in the control group.
- Validity criteria fulfilled:
- yes
- Conclusions:
- No immobility and no abnormal response were observed in the exposure level during exposure. The 24-hour and 48-hour EC50s of the test item for Daphnia magna were >100 mg/L.
Reference
This study was conducted as a limit test to confirm that the test item has no effects on the test organisms at the maximum concentration (100 mg/L) on applied test guidelines. The measured concentrations of the test item in the test solution were maintained within ± 20% of the nominal concentration. At the end of the exposure, 3-methoxy-3-methylbutan-1-ol existed slightly in the test solution and acetic acid was not determined. It was decided that the test item and its hydrolysates exerted no effect on the test organisms because no adverse effect was detected in this study. In addition, the environmental conditions were also within the suitable range. It was determined, therefore, that this study complied with the applied test guidelines.
Description of key information
EC50, 48 hours for Daphnia Magna was found to be greater than 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
An acute immobilisation test in Daphnia magna was conducted to assess the effect of the test material on aquatic invertebrates. The study was conducted according to OECD test guideline 202, and in compliance with GLP.
Four replicate vessels each containing five Daphnia were exposed to dilution water containing the test material at a limit nominal concentration of 100 mg/L. Daphnia were observed at 24 hours and 48 hours for immobilisation.
No immobilisation was seen in either the control level or in the test level at either 24 or 48 hours. On this basis the EC50 value for the test material was concluded to be greater than 100 mg/L.
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