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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Lanthanum chloride trihydrate
IUPAC Name:
Lanthanum chloride trihydrate
Details on test material:
- Name of test material (as cited in study report): Rare Earth Solution Code #1455
- Molecular formula (if other than submission substance): LaCl3*3(H2O)
- Physical state: amber liquid
- Concentration of solution: 100%
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Taconic Farms Inc.
- Weight at study initiation: 100 - 150 g
- Fasting period before study: overnight
- Housing: 5 per wire mesh suspended cage
- Diet (Purina Laboratory Chow) and water ad libitum
- Acclimation period: 7 d

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 0.9 mL

RANGE FINDING STUDY
- Concentrations tested: 3980, 6320, and 10000 mg/kg
- 2 animals per concentration
- result: No. dead/No. dosed: 10000 mg/kg: 2/2; 6320 mg/kg: 2/2; 3980 mg/kg: 1/2
Doses:
2820, 3550 and 4470 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 48 hours
- Frequency of observations and weighing: clinical signs were noted immediately after dosing and at 4, 24, and 48 hours; body weights were recorded at dosing and at 48 hours for the survivors.
- Animals found dead or terminated after 48 hours were subjected to a macroscopic examination of the viscera.
Statistics:
LD50 was calculated according to the method of: Litchfield and Wilcoxon, Pharmacol. and Exp. Ther. 96(99): 1499

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 200 mg/kg bw
95% CL:
> 2 883 - < 3 552
Remarks on result:
other: 48 hours; Test substance: Rare Earth Solution Code #1455
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 621 mg/kg bw
95% CL:
> 2 361 - < 2 909
Remarks on result:
other: 48 hours; Test substance: Lanthanum chloride, anhydrous
Mortality:
4470 mg/kg: 8 out of 10 died within 24 h, 1 out of 10 died within 48 h
3550 mg/kg: 6 out of 10 died within 24 h, 2 out of 10 died within 48 h
2820 mg/kg: 2 out of 10 died within 24 h, no further deaths within 48 h
Clinical signs:
other: 4470 mg/kg: all animals were prostate after dosing and at 4 h. 3550 mg/kg: all animals were lethargic after dosing and didn´t recover until they died or were sacrificed. 2820 mg/kg: all animals were lethargic after dosing and at 4 h; after 24 h 2 animals
Gross pathology:
4470 mg/kg: dead animals: test solution in stomach and intestine; sacrificed animal: no gross pathology - Diarrhea
3550 mg/kg: dead animals: test solution in stomach and intestine; sacrificed animals: no gross pathology - Diarrhea
2820 mg/kg: dead animals: test solution in stomach and intestine; sacrificed animals: no gross pathology (3 animals) or distended stomachs (5 animals)
No gross pathology was performed with surviving animals.

Any other information on results incl. tables

Mortality:

Concentration (mg/kg)

Mortality: No. Dead / No. Dosed

4 h

24 h

48 h

males

 

 

 

4480

0/5

4/5

1/5

3550

0/5

4/5

0/5

2820

0/5

2/5

0/5

females

 

 

 

4480

0/5

4/5

0/5

3550

0/5

2/5

2/5

2820

0/5

0/5

0/5

Applicant's summary and conclusion