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EC number: 200-826-3 | CAS number: 74-97-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bromochloromethane
- EC Number:
- 200-826-3
- EC Name:
- Bromochloromethane
- Cas Number:
- 74-97-5
- Molecular formula:
- CH2BrCl
- IUPAC Name:
- bromo(chloro)methane
- Reference substance name:
- 2008263
- IUPAC Name:
- 2008263
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A local supplier to the testing laboratory
- Age at study initiation: at least 6 weeks old
- Weight at study initiation: less than 3.5 kg
- Housing: in labelled cages with perforated floors
- Diet :Standard laboratory diet
-Water: Free access to tap-water diluted with decalcified water.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
Room temperature: 21oc
Relative humidity: 50%
air exchange rate: 15 changes per hour, 12 hr light and 12 hr darkness
IN-LIFE DATES: NDA
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Amount / concentration applied:
- 0.5 ml of BROMOCHLOROMETHANE
- Duration of treatment / exposure:
- Only 1 dose, the skin area was banded after application for 4 hours.
- Observation period:
- For Mortality- twice daily
For Toxicity- at least once daily
For Irritation- after removal of dressing-1, 24, 48, 72 hr. and 7, 14, 21 days. - Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: afetr 1, 24, 72 h and 7 and 14 days
- Score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: after 21 days
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: after 24, 48, 72h and 7 and 14 days
- Score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: after 21 days
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: afetr 1, 24, 72 h and 7 and 14 days
- Score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: after 1h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: after 1 and 24 hr
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: after 48h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: after 7 days
- Remarks on result:
- other: No scoring possible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: after 21 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: after 14 days
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: after 21 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: after 1 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: afetr 24, 48, 72 hr
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: after 7 and 14 days
- Remarks on result:
- other: No scoring possible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: after 21 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: after 1 and 24h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: after 48 and 72 hr
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: after 7 and 14 days
- Remarks on result:
- other: No scoring possible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: after 21 days
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Necrosis signs appeared and formation of scar tissue.
Dermal application of CBM for 4 hr resulted in full thickness destruction of the skin.
Therefore CBM wasconsidered to be corrosive - Executive summary:
A primary skin irritation/corrosion study was performed on Bromochloromethane using 3 albino rabbits with weights less than 3.5 kg (4 hour exposure, tests sites intact) representing a worst case scenario for assessing irritation.
Erythema and edema were observed within 1 hour after exposure in one rabbit. Superficial grey/white discolouration of the skin (signs of superficial necrosis) and slight or moderate oedema were noted in the other 2 rabbits. Clear signs of necrosis had developed in all 3 rabbits within 24 hours after exposure. Based on the signs of necrosis and resulting formation of scar tissue, it was concluded that BROMOCHLOROMETHANE is considered to be corrosive.
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