Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-525-2 | CAS number: 7173-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 7, 1991 - May 28, 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Didecyldimethylammonium chloride
- EC Number:
- 230-525-2
- EC Name:
- Didecyldimethylammonium chloride
- Cas Number:
- 7173-51-5
- Molecular formula:
- C22H48N Cl
- IUPAC Name:
- didecyldimethylammonium chloride
- Details on test material:
- - Name of test material: DDAC (52% active)
- Physical state:Clear, colourless liquid
- Analytical purity:No data
- Composition of test material, percentage of components: 52% Didecyldimethylammonium chloride, 28% water and 10% isopropanol
- Purity test date:13.06.1991
- Lot/batch No.:E06156439
- Expiration date of the lot/batch: Atleast 2 years from the date of manufacture
- Stability under test conditions:Stable
- Storage condition of test material:Darkness at room temperature in a fume cupboard
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Hoechst AG, Kastengrund, Conventional breed
- Age at study initiation:3-5 months
- Weight at study initiation:3.2-3.8 kg
- Housing:Separate cages
- Diet (e.g. ad libitum):Altromin 2123 rabbit maintenance diet
- Water (e.g. ad libitum):Deionised, chlorinated water
- Acclimation period:No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C):18±3ºC
- Humidity (%):55±20%
- Air changes (per hr):No data
- Photoperiod (hrs dark / hrs light):12 hrs/12 hrs
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 mL
- Concentration (if solution):Neat - Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- 30-60 min, 24, 48 and 72 hrs
- Number of animals:
- Six, three for 3-min exposure and three for 4-hr exposure
- Details on study design:
- TEST SITE
- Area of exposure:2.5X2.5 cm2
- Type of wrap if used:Surgical plaster covered with semi-occlusive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done):with warm tap water
- Time after start of exposure:4 hours
SCORING SYSTEM:Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3 min exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days in the 3-min exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 h in the 4 h exposure group
- Irritant / corrosive response data:
- Exposure to the test substance for 4 hours resulted in well-defined to severe erythema as well as very severe edema from 30 minutes upto 72 hours after removal of patches. Additionally, the skin surfaces was largely discolored, dry, rough and scabbed.
Exposure to the test substance for 3 min resulted very slight edema and from 30 min to 72 hours after removal of the patches. Additionally very slight to severe erythema were observed upto 7 days. Additionally, the skin surfaces was largely discolored, dry, rough and leather-like. - Other effects:
- None
Any other information on results incl. tables
All animals in the 4 hour exposure group were sacrificed after the 72 hour observation period.
Applicant's summary and conclusion
- Conclusions:
- Based on the study results, the test substance is considered to be corrosive to skin.
- Executive summary:
A study was carried out in rabbits to determine the primary dermal irritation of the test substance according to OECD guideline and EU method, under GLP conditions. Dorsal hair is removed by clipping in 6 animals and the neat test substance was applied to the clipped skin under a semi-occlusive bandage. The animals were divided into two groups according to the exposure period - 3 -minute and 4 -hours exposure groups. After removal of the patches, the skin is observed for signs of irritation. In this study, the 4 h exposure produced severe erythema and severe edema up to the 72 h observation period and the skin appeared rough, dry, scabbed with discoloration. The 3 minute exposure produced slight erythema, slight to severe edema up to 7 days and at end of 14 day observation period, the skin appeared dry, rough and leather-like. The mean score for edema and erythema was 4 up to the observation period of 72 h. Based on the study results, the test substance was found to be corrosive to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.