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EC number: 271-808-0 | CAS number: 68608-89-9 This substance is identified by SDA Substance Name: C11-C13 branched alkyl benzene sulfonic acid sodium salt and SDA Reporting Number: 25-097-04.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to a guideline dermal irritation study of the analogue substance linear CaDDBS, the primary dermal irritation score of linear CaDDBS was 7.0, indicating that BABS Na salt is a primary dermal irritant.
In an eye irritation study also performed on the analogue substance linear CaDDBS, rabbits were exposed to 0.1 ml of 100% test substance in the eye for 24 hrs. Results show that the test substance may cause serious damage to the eyes, and therefore BABS Na salt is also likely to cause serious damage to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP laboratory study
- Qualifier:
- according to guideline
- Guideline:
- other: FHSA/CPSC Design, 16 CR 1500
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kuiper Rabbitry, Gary, Indiana
- Age at study initiation: 8 to 10 weeks old
- Weight at study initiation: Not stated
- Housing: Individually housed in stainless steel cages in a temperature, humidity and light controlled room in accordance with the recommendations contained in the National Academy Press 1996 "Guide for the Care and Use of Laboratory Animals."
- Diet (e.g. ad libitum): ad libitum Purina Rabbit Chow
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 4 days - Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observed at 4.5, 24, 72, 168 and 336 hours after application
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch square for each site
- Type of wrap if used: two layer gauze patch secured with non-irritating porous adhesive tape and then the entire site was covered with a 4 mil plastic and secured with more adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess removed after 4 hours
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize Scoring system - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Average of 24 and 72 hour scores
- Score:
- 7
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritant / corrosive response data:
- See table
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
- Conclusions:
- The test substance is a primary dermal irritant.
- Executive summary:
The test substance, Ninate 60E (Branched CaDDBS), was tested for primary dermal irritation in accordance with FHSA/CPSC Guidelines. The sample was applied at a dose of 0.5 mL per site to unabraded and abraded skin sites in a clipped area of each of three albino rabbits. The test sites were occluded and the test material remained on the skin for a 4 hour contact period. Application sites were graded using the Draize scoring system at 4.5, 24, 72, 168 and 336 hours after application. The primary dermal irritation score was 7.0, indicating that the substance is a primary dermal irritant. Based on these results, BABS Na salt is classified as CLP category 2 (irritant) and under DSD is classified as R38, irritating to skin.
Reference
Primary Dermal Irritation
Rabbit Number |
4.5 hours |
|||
Unabraded |
Abraded |
|||
ER |
ED |
ER |
ED |
|
274 |
3 |
4 |
3 |
4 |
275 |
3 |
4 |
4 |
4 |
276 |
3 |
4 |
3 |
4 |
Average |
3.0 |
4.0 |
3.3 |
4.0 |
Rabbit Number |
24 hours |
|||
Unabraded |
Abraded |
|||
ER |
ED |
ER |
ED |
|
274 |
3 |
4 |
3 |
4 |
275 |
3 |
4 |
3 |
4 |
276 |
3 |
4 |
3 |
4 |
Average |
3.0 |
4.0 |
3.0 |
4.0 |
Rabbit Number |
72 hours |
|||
Unabraded |
Abraded |
|||
ER |
ED |
ER |
ED |
|
274 |
4 |
2 |
4 |
2 |
275 |
4 |
4 |
4 |
4 |
276 |
4 |
3 |
4 |
3 |
Average |
4.0 |
3.0 |
4.0 |
3.0 |
Rabbit Number |
7 days |
|||
Unabraded |
Abraded |
|||
ER |
ED |
ER |
ED |
|
274 |
4 |
1 |
4 |
1 |
275 |
4 |
1 |
4 |
1 |
276 |
4 |
1 |
4 |
1 |
Average |
4.0 |
1.0 |
4.0 |
1.0 |
Rabbit Number |
14 days |
|||
Unabraded |
Abraded |
|||
ER |
ED |
ER |
ED |
|
274 |
2 |
1 |
2 |
1 |
275 |
2 |
1 |
3 |
1 |
276 |
2 |
1 |
2 |
1 |
Average |
2.0 |
1.0 |
2.3 |
1.0 |
ER = Erythema; ED = Edema
24 hour score: 14.0
72 hour score: 14.0
Total score: 28.0
Primary dermal irritation score: 7.0
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study done according to OECD Guideline 405, but limited information given in the study report.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: New Zealand
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hrs
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hrs - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- > 1 - < 3
- Remarks on result:
- other: May cause serious damage to eyes
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is classified as R41, may cause serious damage to eyes, under the DSD.
- Executive summary:
Rabbits were exposed to 0.1 ml of 100% test substance (Branched CaDDBS) in the eye for 24 hrs. Results show that the test substance may cause serious damage to the eyes. Based on these results, BABS Na salt is classified as a severe irritant (CLP category 1) with a risk of severe damage to the eyes (DSD (R41)).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In cases where data on BABS Na salt is not available, data on analogue substances are used. The analogue substances used included: 1) the sodium salt of linear alkylbenzene sulfonate (commonly known as LAS or Na-LAS), 2) the calcium salt of branched alkylbenzene sulfonate (commonly known as Branched CaDDBS) and 3) the calcium salt of linear alkylbenzene sulfonate (commonly known as Linear CaDDBS). LAS is the sodium salt of linear alkylbenzene sulfonic acid with alkyl carbon chain lengths ranging from C10 to C13 and averaging 11.6. The primary structure is a C10 to C13 linear alkyl chain with a para-substituted benzene sulfonic acid sodium salt group attached at any of the secondary alkyl carbon positions. Branched CaDDBS is the calcium salt of branched alkylbenzene sulfonic acid with alkyl chain lengths ranging from C11 to C13. Linear CaDDBS is the calcium salt of linear alkylbenzene sulfonic acid with alkyl carbon chain lengths ranging from C10 to C14. BABS Na salt is the sodium salt of branched alkylbenzene sulfonic acid with alkyl chain lengths ranging from C11 to C13. The primary difference between LAS and BABS Na salt is the alkyl chain, branched vs. linear. The primary difference between Branched CaDDBS and BABS Na salt is the salt, calcium vs. sodium. Given their structural and functional similarities, LAS, Branched CaDDBS, and Linear CaDDBS are good analogues for read-across for instances where data are available on them but not on BABS Na salt. When studies on the analogues are available, all data are provided and the most conservative (most health protective) data is used for classification and labeling.
The substance linear CaDDBS was tested for primary dermal irritation in accordance with FHSA/CPSC Guidelines. The sample was applied at a dose of 0.5 mL per site to unabraded and abraded skin sites in a clipped area of each of three albino rabbits. The test sites were occluded and the test material remained on the skin for a 4 hour contact period. Application sites were graded using the Draize scoring system at 4.5, 24, 72, 168 and 336 hours after application. The primary dermal irritation score was 7.0, indicating that the substance is a primary dermal irritant. This was the most conservative value of the four dermal irritation studies presented. The remaining three read-across studies also had a result of irritating to skin.
In a linear CaDDBS study, rabbits were exposed to 0.1 ml of 100% test substance in the eye for 24 hrs, according to OECD guideline 405. Results show that the test substance may cause serious damage to the eyes. The additional four read-across studies had results ranging from irritating to irreversible damage to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
The selected study represents the conservative results, with a primary irritation index of 7.
Justification for selection of eye irritation endpoint:
The selected study was one of two studies performed on analogue substances that had the most conservative result, irreversible damage to the eyes with a irritation score of up to 3.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
With regards to skin irritation, BABS Na salt is classified as CLP category 2, irritant, and under DSD is classified as R38, irritating to skin. For eye irritation, BABS Na salt is classified as a severe irritant (CLP category 1), with risk of severe damage to the eyes (R41).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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