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EC number: 213-235-0 | CAS number: 931-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: Mallory VT (1993) performed a K2 primary dermal irritation study to assess the skin irritation potential of glycerine carbonate in New Zealand White rabbits according to a method equivalent to OECD Guideline 404. Glycerine carbonate was not observed to be irritating to the skin. This study was selected as key study.
Eye irritation:
Based on the data of a study performed similar to OECD Guideline 405 study, glycerine carbonate was shown not to be irritating to the eyes (Mallory VT, 1993).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a primary dermal irritation study in rabbits, glycerine carbonate was applied to five sites on the dorsal trunk of six rabbits (3 males/3 females) at 0.5 mg/site. The exposure periods for the two intact upper dorsal sites were 3 and 60 minutes, respectively. The exposure period for the one intact mid dorsal site was 4 hours. The exposure period for the two lower sites (one intact and one abraded) was 24 hours. All sites were scored immediately and at 21, 48 and 72 hours after unwrapping.
No signs of erythema, edema or necrosis were observed at any observation period at the 3 and 60 minute, 4 and 24 hour (intact and abrased) exposure sites. The study was terminated following the 72 -hour observation period.
The test article was considered to be a non-irritant at both 4 and 24 hour exposure.
Eye irritation
In the key study by Pharmakon Research (1993), 6 rabbits were instilled 0.1 ml of undiluted test substance in one eye, while the other eye served as control. The eyes were examined at 1, 24, 48 and 72 hours after treatment. Positive ocular responses were observed at 1, 24, 48 and 72 hours. A Maximum mean total score (MMTS) of 6.3 was recorded after 1 hour but was fully reversible, and given the low scores regarding the cornea (0 of 4), iris (0 of 4) and conjunctivae (<1 of 3) at the 24,48 and 72 h, no adverse effect on eyes were observed. All ocular scores returned to normal at 72 hours and the study was terminated. Based upon the observations made in the primary eye irritation study, the test article was determined not to be an eye irritant. Hence, according to the criteria of the DSD and CLP Regulation the substance should not be classified as irritating to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available
Justification for selection of eye irritation endpoint:
Only one study available
Justification for classification or non-classification
Based on the available data and the criteria of the DSD and CLP Regulation, glycerine carbonate should not be classified as a skin irritant.
According to the results of the eye irritation study and the criteria of the DSD and CLP Regulation, glycerine carbonate should not be classified as an eye irritant.
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