Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 294-785-9 | CAS number: 91770-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegraadation
The test item cannot be declared readily biodegradable but was determined to be rapidly degradable. At the end of the 35-day test period in the key study, the activated sludge inoculum was active, degrading the reference substance 94.1 % and, as a UVCB, the test item may be considered rapidly biodegradable since the pass level of 60% of ThIC was achieved within 28 days (OECD 310).
Adsorption/desorption
The absorption coefficient of the test item has been determined to be > 4.27 E+05 (Log Koc≥5.63). The test substance has low mobility in soil.
Additional information
Biodegradation
Key study
In the key Headspace Test conducted in accordance with OECD Guideline 310, inoculated test medium was dosed with a known amount of test substance as the nominal sole source of organic carbon and sealed. CO2 evolution from the ultimate aerobic biodegradation of the test substance is determined by measuring the inorganic carbon (IC) produced in the test bottles over that produced in the blank control bottles. The amount of IC produced by the test substance (corrected for that evolved by the controls and the amount added by basification, where applicable) is expressed as a percentage of the theoretical amount of IC (ThIC) that could have been produced if complete biodegradation of the test substance occurred. The test contained a control group, a reference group and a treatment group. Each group contained twenty-seven replicate test chambers. The control chambers were used to measure the background IC production of the inoculum medium and were not dosed with a carbon source. The reference chambers were dosed with 1-octanol, a substance known to be biodegradable, at a nominal concentration of 20 mg C/L. The treatment group test chambers were used to evaluate the test item at a nominal concentration of approximately 20 mg C/L.
The results at the end of the 35-day test period indicated that the activated sludge inoculum was active, degrading the reference substance 94.1 %. The average cumulative percent biodegradation for the test item was 73.1 %.
The test item may not be considered readily biodegradable under aerobic conditions since biodegradation ≥ 60 % ThIC was not achieved within a 10-day window of reaching 10 % ThIC. However, as a UVCB, the test item may be considered rapidly biodegradable since the pass level of 60 % of ThIC was achieved within 28 days.
Supporting study
The supporting study was conducted according to the procedures outlined in the protocol "Ready biodegradability by the carbon dioxide evolution test method". The protocol was based on the procedures specified in the OECD guideline for testing of chemicals, Methods 301B, and EEC Method C.4-C.
The viability of the inoculum and validity of the test were supported by the results of the reference substance, sodium benzoate, from which 99.3% of theretical CO2 was evolved. An average percent biodegradation of greater than 60% was achieved within 7 days, thereby fulfilling the criteria for a valid test by reaching the pass level by day 14. The average cumulative percent of theoretical carbon dioxide produced by the test substance at 10 mg C/L was 57.0%.
Evidence of ready biodegradability in a carbon dioxide evolution test is 60 % TCO2 within the 28-d test period. In addition, the pass value must be reached within 10 days of achieving 10 % TCO2. The test item may not be considered readily biodegradable under the conditions tested since the pass level of 60 % TCO2 was not achieved. However since tests of ready biodegradability provide limited opportunity for biodegradation to occur, a negative result does not mean that the test substance will not be biodegraded under relevant environmental conditions.
Abiotic degradation; Hydrolysis
The study does not need to be conducted because the substance is highly insoluble in water. The experimentally determined water solubility was < 4.93 mg/L at 20 °C (OECD 105 and EU Method A.6). However, the final result was considered to be higher than the actual water solubility of the test item and the calculated value given by WSKOW v1.41 (2000, US EPA) was 4.3E-16 mg/L based on structural information.
Bioaccumulation
An experimental investigation does not need to be conducted if the substance has a low potential for bioaccumulation. The experimentally derived Log Pow value for the substance has been identified as > 9.4, with extrapolation to a Log Pow value of 11.7. A QSAR calculation of Log Pow gave the estimated value of Log Pow as 16.6. ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R11: PBT assessment (Version 3.0; June 2017) states that the aquatic BCF of a substance is probably lower than 2000 L/kg if the calculated log Kow is higher than 10. A study is therefore considered scientifically unjustified with regard to the low bioaccumulative potential of the substance.
Transport and distribution
Adsorption/desorption
The absorption coefficient of the test item has been determined to be > 4.27 x 10E+05 (Log Koc ≥ 5.63). The test substance has low mobility in soil.
Henry's Law Constant
The value of Henry’s constant (25 °C) was calculated as 0.041 Pa/m3/mol (EUSES 2.1.2).
Distribution modelling
The substance is predicted to partition mainly to soil (33.1 %) and sediment (64.1 %).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.