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EC number: 213-926-7 | CAS number: 1067-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-11-30 to 1994-12-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Test substance concentration was determined in the stock solution used to prepare the test media and in the control as well as all treatments at the start and end of the test.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A 1000 mg/L stock solution in synthetic freshwater was prepared by mixing for 18 hours followed by filtration. The test media were prepared by dilution of the stock solution. The measured DOC concentration in the stock solution was 398 mg/L which was equivalent to 907 mg/L of the test substance.
- Controls: Dilution water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Clone 5
- Source: In-house stock culture
- Age at study initiation: <24 h
- Feeding during test: None
METHOD OF BREEDING
- Method of breeding: Parthenogenetic reproduction
- Breeding conditions: The Daphnia are held in 1 L glass beakers filled with M4-medium (Elendt 1990).
- Maintenance: Every 2 to 3 d, water is renewed, exuviae and juveniles are removed from the beakers.
- Food type: Scenedesmus subspicatus
- Amount of food: As much as is consumed, leaving no residue
- Feeding frequency: Daily
- Other: Red/dark-brown coloring of the organisms is considered healthy.
- Other: Every 4 weeks, juveniles are isolated and used for further breeding.
ACCLIMATION
- Acclimation period: 24 h before test start
- Acclimation conditions (same as test or not): Yes
- Other: 24 h before test start, the mother organisms are isolated. The juveniles that hatch over night are used for the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- The sum of the Ca2+ and Mg2+ ions was 2.5 mmol
- Test temperature:
- 20 +/-1ºC
- pH:
- 7.8
- Dissolved oxygen:
- 8.2 - 8.4 mg/l
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0 (control), 54, 91, 163, 272, 481 and 816 mg/l
Measured (0 h): 0, 58, 92, 190, 270, 488, 814 mg/L
Measured (48 h): 0, 57, 90, 166, 266, 475, 785 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass cylinder
- Type: Open
- Specifications: Glass vessel, containing 10 ml of test medium
- Aeration: None
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 2 mL per organism
- Feeding: None
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 medium
- Intervals of water quality measurement: end of test
OTHER TEST CONDITIONS
- Photoperiod: Dark
EFFECT PARAMETERS MEASURED:
Immobilization after 24 and 48 h exposure
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.7 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 816 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 816 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0
- Other adverse effects control: None reported - Results with reference substance (positive control):
- EC50 (48 h) > 1.0, < 2.0 mg/l
- Reported statistics and error estimates:
- The were no toxic effects observed in the highest test concentrations and therefore statistical analysis of the results was not carried out.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-h EC50 obtained for the short-term toxicity of the substance toward aquatic invertebrates was >816 mg/L and the NOEC ≥816 mg/L based on nominal concentrations of the substance. However, it is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
ANALYTICAL RESULTS
A deviation of < 20% was obtained for the geometric mean values of the measured concentrations at 0 and 48 h. Therefore, > 80% of the test concentration remained during the testing period and the results were based on the nominal concentrations.
EXPERIMENTAL RESULTS
Table 1. Test results
Nominal test concentration (mg/l) | Mean percentage immobilisation after 24 hours | Mean percentage immobilisation after 48 hours |
0 (Control) | 0 | 0 |
54 | 0 | 0 |
91 | 0 | 0 |
163 | 5 | 5 |
272 | 5 | 5 |
481 | 0 | 0 |
816 | 0 | 0 |
Description of key information
EC50 (48 h) > 816 mg/L (nominal, EU method C2, D. magna, RL 1), equivalent to 607 mg/L when expressed in terms of the silanol hydrolysis product
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- 48 h
- Effect concentration:
- > 607 mg/L
Additional information
A 48-h EC50 value of >816 mg/l and a NOEC of ≥ 816 mg/l (EU Method C.2 (Acute Toxicity for Daphnia) was obtained for the short-term effects of the test substance on the mobility of Daphnia magna based on nominal concentrations.
Since the substance hydrolyses rapidly (half-life approximately 2.6 hours) to propysilanetriol, under ecotoxicity testing conditions, the organisms were predominantly exposed to the hydrolysis product.
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