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Diss Factsheets
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EC number: 215-385-2 | CAS number: 1324-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: old study without GLP, but fulfill basically scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Alkali Blue GG (CP-1816)
- IUPAC Name:
- Alkali Blue GG (CP-1816)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Alkali Blue GG (CP-1816) was received from the Sherwin Williams company and evaluated for its oral toxicity in rats.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Ten albino Sprague-Dawley rats (5 male, 5 female) were obtained from Taconic Farms. The rats were housed five to a cage and fed Purina Laboratory Chow and water at ibiturn.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Following a brief acclimation period, the rats were fasted overnight then gavaged with the test material at the rate of 5 gm/kg of body weight.
- Doses:
- 5000 mg/kg of body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Ten albino Sprague-Dawley rats (5 male, 5 female) were obtained from Taconic Farms. The rats were housed five to a cage and fed Purina Laboratory Chow and water 1 ibiturn. Body weights were recorded at dosing and on Day 14. Observations were made frequently after dosing and daily until termination. Animals sacrificed at Day 14 were subjected to a gross examination of the viscera.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No animals died during the 14-day observation period, No signs of toxicity were noted after administration. Body weight gain was good. No observations were noted at necropsy.
- Mortality:
- No animals died during the 14-day observation period.
- Clinical signs:
- No signs of toxicity were noted after administration.
- Body weight:
- Body weight gain was good.
- Gross pathology:
- No observations were noted at necropsy.
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results given in this study, test article is considered non-toxic. LD 50(oral, rats) is estimated at greater than 5000 mg/kg of body weight.
- Executive summary:
An acute oral toxicity study of test article was conducted in young albino rats. Ten Sprague-Dawley rats were exposed at the level of 5000 mg/kg of body weight. Body weights were recorded at dosing and on day 14. Observations were made frequently after dosing and daily until termination. Animals sacrificed at Day 14 were subjected to a gross examination of the viscera. Based on a 100% survival rate at 5000mg/kg of body weight, test article was considered as non-toxic. The LD50 would be estimated at greater than 5000 mg/kg of body weight.
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