Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-784-1 | CAS number: 99-75-2
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insifficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- A study of embryotoxic and teratogenic action of some industrial substances formed during production of dimethylterephthalate
- Author:
- Krotov YA & Chetobar NA
- Year:
- 1 972
- Bibliographic source:
- Gig. Truda Prof. Zabol, Vol. 16, 40-43
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- Maternal effects in developmental toxicity study
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- other: vapour
- Details on test material:
- - Name of test material (as cited in study report): paratoluic methylate (PTE)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: white
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 24 h per day for 20 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150 mg/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- 29 pregnant females
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- ca. 150 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: maternal toxicity in developmental toxicity study
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Maternal effects of the study were not stated, but effects from former examinations at "similar exposure concentrations" were reported to be altered activity of cholinesterase, altered chronaxy, blood proteins and histomorphology (no further details)
Applicant's summary and conclusion
- Conclusions:
- No definite conclusions can be drawn because of insufficient documentation of exposure conditions and effects observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
