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EC number: 287-634-3 | CAS number: 85566-24-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 75.3% (BOD) after 28 d (OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of Fatty acids, C14-18, C14-18-alkyl esters (CAS 85566-24-1) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance docosyl docosanoate (CAS 17671-27-1) was conducted. The read-across substance is representative to evaluate the biodegradation of the target substance. Docosyl docosanoate is characterized by a longer fatty acid chain length (C22) and a longer fatty alcohol chain length (C22) compared to the target substance. It can thus be used for read-across as a worst case approach since the chain length of the fatty alcohol and the fatty acid are the determining factor for biodegradation. Moreover, reliable (Q)SAR data performed for the target substance indicate that the substance is readily biodegradable.
The study with the source substance docosyl docosanoate was
performed according to OECD 301C (GLP) under aerobic conditions using a
mixture of activated sludge from STP with freshwater from rivers and
lakes, marine water and marine sediment as inoculum with a test
substance concentration of 100 mg/L (Ministry of Economy, Trade and
Industry, Japan, 1992). A biodegradation of 75.3% (BOD) was observed
after 28 d. Since the substance reached the pass level for OECD 301C
(biodegradation is > 60% after 28 d, no 10-day window required) docosyl
docosanoate is readily biodegradable according to the OECD criteria.
Supporting (Q)SAR predictions using VEGA v1.0.8 showed that the main
components of the UVCB target substance are readily biodegradable. The
prediction is valid and reliable as all constituents are within the
training set of the model. Similar molecules with experimental data were
found within the training set showing that the substance is readily
biodegradable. This result supports the experimental study with a
structurally very similar source substance as discussed above.
Based on the results from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) in combination with reliable (Q)SAR data for the target substance it can be concluded that Fatty acids, C14-18, C14-18-alkyl esters is readily biodegradable according to the OECD criteria.
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