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EC number: 473-690-8 | CAS number: 738602-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 2005 - Feb 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 473-690-8
- EC Name:
- -
- Cas Number:
- 738602-93-2
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- (2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,5R)-4-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: Sponsor, Batch 4G08
- Purity, including information on contaminants, isomers, etc.: 54.2 % Maltotriosyl glucoside
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature at about 20 °C away from direct sunlight
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- 100 µl aliquots of the test solutions at each pH value were analysed without dilution by measuring the ELSD signal of MG-60 after HPLC separation of the injected sample solution.
- Buffers:
- buffer pH 4:
6.8 g potassium dihydrogen phosphate were dissolved in 1000 ml of water and adjusted to pH 4.0 with phosphoric acid
Buffer pH 7:
obtained from Baker
Buffer pH 9
obtained from Fluka - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: not stated
- Sterilisation method: rinsing with sterile buffer
- Lighting: not stated
- Measures taken to avoid photolytic effects: not stated
- Measures to exclude oxygen: glassware stoppered with inert material, nitrogen was passed through the test solutions for 5 miunutes
- Details on test procedure for unstable compounds: substance is stable
- Details of traps for volatile, if any - none
- If no traps were used, is the test system closed
- Is there any indication of the test material adsorbing to the walls of the test apparatus? not stated
TEST MEDIUM
- Volume used/treatment 100 ml, in two aliquotes
- Kind and purity of water: Water prepared by Milli-Q supply
- Preparation of test medium: test item is solved in an appropriate amount of buffer
- Renewal of test solution: no
- Identity and concentration of co-solvent: none used
OTHER TEST CONDITIONS
- Adjustment of pH: not stated
- Dissolved oxygen: not stated
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 25
- Initial conc. measured:
- >= 68.65 - <= 69.5 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 25 °C
- Remarks:
- Due to interferences from the buffer salts, the test item peak could not be separated from the peak of the buffer solutions at pH 4 and pH7, respectively.
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 25 °C
- Remarks:
- Due to interferences from the buffer salts, the test item peak could not be separated from the peak of the buffer solutions at pH 4 and pH7, respectively.
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- not specified
- Statistical methods:
- mean value calculated
Results and discussion
- Preliminary study:
- Only a preliminary study was done.
- Test performance:
- Due to interferences from the buffer salts, the test item peak could not be separated from the peak of the buffer solutions at pH 4 and pH 7, respectively. Thus, the test item could not be detected in these buffer solutions. Hence, no hydrolysis experiments could be performed at pH 4 and pH 7.
- Transformation products:
- not measured
Dissipation DT50 of parent compound
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- Due to interferences from the buffer salts, the test item peak could not be separated from the
peak of the buffer solutions at pH 4 and pH 7, respectively. Thus, the test item could not be
detected in these buffer solutions. Hence, no hydrolysis experiments could be performed at
pH 4 and pH 7.
The hydrolytic stability of the test item was therefore assessed from its chemical structure:
The test item contains only ether functional groups R-O-R’ that could potentially be
susceptible to hydrolytic degradation. Ether cleavage of the functional ether types present in
the test item most commonly would occur via a reaction mechanism according to SN2. The
pKa of ethers is in the range from –2 to -41). That requires strong acids like hydrochloric acid
(HCl) or hydrobromic acid (HBr) for the ether cleavage. At environmental pH’s in the range
from 4 to 9, ethers are known to be stable and it is very unlikely that hydrolysis will occur.
The experimental results of pH 9.0 showed no significant degradation of MG-60 at 50°C. The
degradation of MG-60 was less than 10 % after 5 days. According to the EEC Directive 92/69,
Section C.7, it can be concluded, that the estimated half-life time is higher than one year
under representative environmental conditions (25°C). Therefore, MG-60 was considered to
be hydrolytically stable, and no further testing was necessary.
In conclusion, the test item MG-60 contains no functional groups that can be hydrolysed in
the pH range from 4 to 9. The test item will therefore be hydrolytically stable in the
environmental pH range from 4 to 9. The hydrolytically stability at pH 9 was also verified by
experimental testing.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In conclusion, the test item MG-60 contains no functional groups that can be hydrolysed in
the pH range from 4 to 9. The test item will therefore be hydrolytically stable in the
environmental pH range from 4 to 9. The hydrolytically stability at pH 9 was also verified by
experimental testing. - Executive summary:
The hydrolysis determination of MG-60 at different pH values was based on the OECD
Guideline No. 111, “Hydrolysis as a Function of pH”; adopted May 12, 1981 and on the EEC
Directive 92/69, Section C.7, “Abiotic Degradation: Hydrolysis as a Function of pH”, L383 A,
December 1992.Due to interferences from the buffer salts, the test item peak could not be separated from the
peak of the buffer solution. Thus, the test item could not be detected in buffer solutions at
pH 4 and pH 7, respectively. Hence, no hydrolysis experiments could be performed at pH 4
and pH 7. The hydrolytic stability of the test item was therefore assessed from its chemical
structure. Thus, it is very unlikely that hydrolysis will occur.The experimental results of pH 9.0 showed no significant degradation of MG-60 at 50°C. The
degradation of MG-60 was less than 10 % after 5 days. According to the EEC Directive 92/69,
Section C.7 it can be concluded, that the estimated half-life time is higher than one year
under representative environmental conditions (25°C). Therefore, MG-60 was considered to
be hydrolytically stable at pH 9.0, and no further testing was necessary.
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