Registration Dossier
Registration Dossier
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EC number: 228-207-3 | CAS number: 6168-72-5
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- DL-2-aminopropan-1-ol
- EC Number:
- 228-207-3
- EC Name:
- DL-2-aminopropan-1-ol
- Cas Number:
- 6168-72-5
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 2-aminopropan-1-ol
1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- at initiation (0-hour) and 24 hours, and in a composite of replicate spent solution samples at 24 and 48 hours (termination) of the definitive test.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 0, 6.3, 13, 25, 50, and 100 mg 2-Aminopropanol/L
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19.6-20.4
- pH:
- 8.5-9.6: test-item dependent increase in pH in fresh solutions
- Nominal and measured concentrations:
- Measured concentrations of 2-Aminopropanol at all 4 sampling occasions ranged 89-105% of the nominal concentrations. Thus, the biological response results are reported based upon the mean measured concentrations of test solutions.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 24.3 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 39.7 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
In a semi-static test, Daphnia EC50(48h) was 39.7 mg/L and NOEC(48h) was 24.3 mg/L, based on mean measured concentrations of DL-2AP.
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