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EC number: 953-917-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- 2 026 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% confidence limits: 1212 - 3035 mg/kg dry sediment
- Key result
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 687 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2 196 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Abnormal behaviour among the Corophium was recorded on day 3 at 95, 977, 3125 and 10000 mg/kg, on day 6 at 977, 3125 and 10000 mg/kg and on day 10 at 977 and 3125 mg/kg.
- Reported statistics and error estimates:
- The LC50 value was calculated by Maximum Likelihood-Weibull (P=0.25) and the NOEC and LOEC values by Fisher's Exact Test using ToxCalc v5.0.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 10-day LC50 of the test item to Corophium volutator was determined to be 2026 mg/kg dry sediment (95% confidence limits 1212 - 3035). The highest no-observed effect concentration (NOEC) after 10-days exosure was 687 mg/kg dry sediment. Abnormal behaviour among the Corophium was recorded on day 3 at 95, 977, 3125 and 10000 mg/kg, on day 6 at 977, 3125 and 10000 mg/kg and on day 10 at 977 and 3125 mg/kg. The water quality measurements of the test solutions were within the ranges specified in the test guideline and this was acceptable. None of the twenty control corophium died during the study and this represents an acceptable level of health of the test organisms maintained under test conditions.
- Executive summary:
The study was performed to investigate the toxicity of the test item to Corophium volutator. The objective of this study was to determine the 10 -day LC50 after a 10 -day exposure period. The toxicity test was carried out according to the testing laboratory SOPs, based on the guidelines produced by the OSPAR/PARCOM Protocols on Methods for the Testing of Chemicals Used in the Offshore Industry 2006 Part A: A sediment bioassay using an amphipod Corophium sp. The study was performed in compliance with GLP. The 10-day LC50 of the test item to Corophium volutator was determined to be 2026 mg/kg dry sediment (95% confidence limits 1212 - 3035). The highest no-observed effect concentration (NOEC) after 10-days exosure was 687 mg/kg dry sediment. Abnormal behaviour among the Corophium was recorded on day 3 at 95, 977, 3125 and 10000 mg/kg, on day 6 at 977, 3125 and 10000 mg/kg and on day 10 at 977 and 3125 mg/kg. The water quality measurements of the test solutions were within the ranges specified in the test guideline and this was acceptable. None of the twenty control corophium died during the study and this represents an acceptable level of health of the test organisms maintained under test conditions.
Reference
Table: Mortality after 10 -days exposure
Nominal concentration (mg/kg) | Number alive* | Total number dead | Mortality | ||
Wet sediment | Dry sediment | Replicate 1 | Replicate 2 | (%) | |
0 (control) | 0 (control) | 10 | 10 | 0 | 0 |
95 | 215 | 6 | 10 | 4 | 20 |
305 | 687 | 9 | 8 | 3 | 15 |
977 | 2196 | 6 | 5 | 9 | 45 |
3125 | 7021 | 1 | 1 | 18 | 90 |
10000 | 22470 | 0 | 0 | 20 | 100 |
* Number exposed in each replicate = 10
Description of key information
The 10-day LC50 under static conditions was determined in compliance with GLP according to OSPAR/PARCOM 2006 Protocol. The mud shrimp corophium volutator was exposed to 5 different test item concentrations ranging from 95 to 10000 mg/kg dry sediment. 20 individuals each concentration plus 20 individuals untreated as a control were exposed for 10 days in natural sediment overlayed by artificial saltwater. Records were made of the number of observed alive as well as any showing abnormal behaviour on days 3, 6 and 10. The 10-day LC50 of the test item to Corophium volutator was determined to be 2026 mg/kg dry sediment (95% confidence limits 1212 - 3035). The highest no-observed effect concentration (NOEC) after 10-days exposure was 687 mg/kg dry sediment.
Key value for chemical safety assessment
- EC50 or LC50 for marine water sediment:
- 2 026 mg/kg sediment dw
- EC10, LC10 or NOEC for marine water sediment:
- 687 mg/kg sediment dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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