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EC number: 472-690-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 - 24 October 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 472-690-5
- EC Name:
- -
- Cas Number:
- 136040-19-2
- Molecular formula:
- C24BF20.C19H15
- IUPAC Name:
- Methylium, triphenyl-, tetrakis(pentafluorophenyl)borate(1-).
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, Horst, The Netherlands
- Age at study initiation: at least 6 weeks old
- Weight at study initiation: at least 1 kg
- Housing: cage with perforated floor
- Diet (e.g. ad libitum): 100 g pelleted diet per day
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days before start of treatment under lab conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.4 - 23.2 C
- Humidity (%): 42-73%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: corn oil
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): since the powdery test substance is not stable in water, the substance was moistened with 0.5 ml corn oil immediately before application to ensure close contact with the animal's skin. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- The study was performed in a stepwise manner and was started by treatment of a single rabbit (sentinel). Since evidence of full thickness destruction of the skin (scar tissue) was obtained, the two other animals were not treated.
- Details on study design:
- TEST SITE
- Area of exposure: 2x3 cm = 6 cm2
- % coverage: 100%
- Type of wrap if used: metalline patch mounted on Micropore tape, wrapped around the abdomen and secured with Coban elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin was cleaned of residual test substance using corn oil.
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
Mortality twice daily, toxicity at least once daily, body weight at day of treatment and termination, irritation at 1, 24, 48 and 72 hours and 7 and 14 days after the removal of the dressings and test substance.
SCORING SYSTEM:
- Method of calculation: erythema 0 - 4, oedema 0 - 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
- 1 hour after exposure: erythema 2, oedema 2, yellow staining of the skin by the test substance
24 hours after exposure: erythema 4, oedema 3
48 hours after exposure: erythema 4, oedema 3, reduced flexibility of the skin
72 hours after exposure: erythema 4, oedema 2, reduced flexibility of the skin and superficial brown discolouration (sign of necrosis)
7 days after exposure: erythema 4, oedema could not be scored due to fissuring of the skin
14 days after exposure: erythema 1, oedema 1, bald skin, noticeably white skin (scar tissue), scaliness - Other effects:
- No symptoms of toxicity were observed, nor mortality occurred.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Evidence of full thickness destruction of the skin (scar tissue) was observed during the observation period, indicating that corrosion of the skin had occurred by dermal application of the test substance to the intact rabbit skin. Based on these results, according to CLP, the substance should be classified as skin corrosive category 1C.
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