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EC number: 640-454-2 | CAS number: 17318-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 15 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 6.5
- Conclusions:
- The water solubility of the test substance was determined to be 15 mg/L at 20 °C.
- Executive summary:
The water solubility of the substance was determined with the flask method under GLP in accordance with OECD TG 105. Pure water with a resistivity of >15 MΩ.cm that had been filtered through a 0.45 μm filter was used in the study.
On the first three days of the main experiment, two dispersions, each containing about two times the amount of material necessary for saturation, were prepared in 100 mL volumetric flask. The contents were then equilibrated by continuous gentle stirring directly at 20.0 °C (± 0.5 °C) in a thermostatically controlled water bath. On the fourth day the temperature of the water bath was reduced to the test temperature of 20.0 °C (± 0.5 °C), at which temperature the test dispersions were then re-equilibrated by continuous gentle stirring for at least further twenty-four hours.
Finally, the dispersions were transferred to stainless steel centrifuge tube and centrifuged for forty minutes at 30000 G or 48000 G, as appropriate, in a centrifuge, thermostated at 20 °C. Afterwards, each centrifuge tube contained a clear, aqueous solution with undissolved, excess test item still present. Subsequently, an aliquot from each clear, centrifuged, saturated solution was removed and analyzed by high performance liquid chromatography (HPLC).
The six samples thus prepared represent the six permutations of two different centrifugation accelerations with three different pre-equilibrium periods (1, 2 or 3 days) at 20.0 °C.
Centrifugation at different G values gave similar results, demonstrating that clear solutions had been obtained by centrifugation. Pre-equilibration for different lengths of time also gave similar results indicating that equilibrium had indeed been reached.
The pH of each saturated solution was determined following centrifugation and was in the range from 6.4 to 6.61.
A comparison of the retention times of the test substance in the reference solutions with those in the sample solutions indicated that the identity of the test item had not altered during the experiment.
Reference
Table 1: Results of the study on water solubility
sample number |
W1 |
W3 |
W5 |
W2 |
W4 |
W6 |
amount of test item [mg] dispersed in |
2.67 |
2.81 |
2.54 |
2.64 |
2.51 |
2.55 |
number of days at |
3 |
2 |
1 |
3 |
2 |
1 |
number of days at |
1 |
1 |
1 |
1 |
1 |
1 |
centrifugation time [minutes] |
40 |
40 |
40 |
40 |
40 |
40 |
centrifugation speed [G value] |
30000 |
30000 |
30000 |
48000 |
48000 |
48000 |
pH of clear solution |
6.67 |
6.49 |
6.67 |
6.41 |
6.40 |
6.41 |
Average pH value |
6.5 |
|||||
water solubility [mg/l] 1stdetermination average |
14.397 14.392 |
13.638 13.623 |
15.700 15.700 |
14.489 14.464 |
16.454 16.441 |
15.413 15.440 |
average [mg/l] |
14.571 |
15.448 |
||||
relative standard deviation [%] |
6.45 |
5.73 |
||||
total average [mg/l] |
15 |
|||||
total relative standard deviation [%] |
6.6 |
Description of key information
The water solubility of the substance has been determined reliably by the flask method under GLP according to OECD TG 105.
Key value for chemical safety assessment
- Water solubility:
- 15 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.