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EC number: 828-215-2 | CAS number: 172796-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 12 September 2018 and 17 November 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt
- EC Number:
- 828-215-2
- Cas Number:
- 172796-84-8
- Molecular formula:
- C8H12NO7P2Na
- IUPAC Name:
- phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt
- Reference substance name:
- 4-aminophenylacetic acid
- EC Number:
- 214-828-7
- EC Name:
- 4-aminophenylacetic acid
- Cas Number:
- 1197-55-3
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 4-aminophenylacetic acid
- Reference substance name:
- EBP dimer
- Molecular formula:
- C16H22N2O12P4
- IUPAC Name:
- EBP dimer
- Test material form:
- solid: particulate/powder
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Identification: Phosphonic acid, [2-(4-aminophenyl)-1-hydroxyethylidene]bis-, monosodium salt (“EBP”)
Appearance/Physical state: Beige colored powder
Batch: CHPC071917EBP
Purity: >90%
Expiry date: 01 July 2019
Storage conditions: Room temperature in the dark
Results and discussion
Water solubility
- Key result
- Water solubility:
- 12.5 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.1
- Details on results:
- The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 50 to 1000 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.
Any other information on results incl. tables
Preliminary Test
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 12.5 g/L. The solution had a pH of 5.2.
Definitive Test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 125 mg/L |
9.166 x 106 |
Standard 133 mg/L[1] |
- |
Matrix blank |
None detected |
Sample 1A |
8.919 x 106 |
Sample 1B |
9.144 x 106 |
Sample 2A |
9.105 x 106 |
Sample 2B |
9.116 x 106 |
Sample 3A |
9.384 x 106 |
Sample 3B |
9.435 x 106 |
[1] The 125 and 133 mg/L standard solutions were noted to be out of agreement, and therefore, one was proposed to be erroneous. Subsequent analysis of the 125 and 133 mg/L standard solutions against duplicate, additional 128 mg/L standard solutions confirmed that the 133 mg/L standard solution was erroneous. Therefore, the 133 mg/L standard solution was not used in any subsequent calculations.
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
12.3 |
7.2 |
2 |
48 |
12.4 |
7.2 |
3 |
72 |
12.8 |
6.8 |
Mean concentration : 12.5 g/L at 20.0 ± 0.5 ºC
Range : 12.3 to 12.8 g/L
Standard Deviation : 0.27 g/L
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item has been determined to be 12.5 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
Water Solubility. 12.5g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
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