4-(cyclohexylamino)butane-1-sulfonic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 April 2019 - 24 May 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

04 March 2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

March 1998

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

475 g/L

Conc. based on:

test mat.

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

7

Remarks on result:

other: The water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.

Details on results:

- Results of preliminary test: The content of test item dissolved in the water sample was 344 g/L.
- Concentration analysed after 24, 48 and 72 hours of stirring: 556 g/L, 467 g/L and 483 g/L, resp.
- The 24-hour measurement was significantly higher than the 48- and 72- hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements (mean difference 3.4%).
- Small responses at the retention time of the test item were detected in the chromatograms of the pretreated sample from the blank water mixture. It was considered that it has no significant effect on the results of the test samples.

Conclusions:

The water solubility of the substance at 20°C was determined to be 475 g/L (flask method).

Executive summary:

The water solubility of 4-(cyclohexylamino)butane-1-sulfonic acid was determined in a test performed according to OECD guideline 105 and GLP principles, using the flask method. 10.0 g of the substance was weighed into glass vessels to which 10 mL double distilled water was added. The vessels were stirred for 24, 48 and 72 hours, after which the water phases were filtered. Liquid chromatography was used for qualitative assessment from samples taken at 24 h, 48 h and 72 h. The results showed a water solubility of 556, 467 and 483 g/L at 24 h, 48 h and 72 h samples, respectively. The the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements. Based on the flask method test, the water solubility of 4-(cyclohexylamino)butane-1-sulfonic acid, at 20°C was 475 g/L.

Description of key information

The water solubility of 4-(cyclohexylamino)butane-1-sulfonic acid at 20°C is 475 g/L using the flask method.

Key value for chemical safety assessment

Water solubility:

475 g/L

at the temperature of:

20 °C

Additional information

The water solubility of 4-(cyclohexylamino)butane-1-sulfonic acid was determined in a test performed according to OECD guideline 105 and GLP principles, using the flask method. 10.0 g of the substance was weighed into glass vessels to which 10 mL double distilled water was added. The vessels were stirred for 24, 48 and 72 hours, after which the water phases were filtered. Liquid chromatography was used for qualitative assessment from samples taken at 24 h, 48 h and 72 h. The results showed a water solubility of 556, 467 and 483 g/L at 24 h, 48 h and 72 h samples, respectively. The the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements. Based on the flask method test, the water solubility of 4-(cyclohexylamino)butane-1-sulfonic acid, at 20°C was 475 g/L.