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EC number: 412-050-4 | CAS number: 125109-85-5 FLORHYDRAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- β-methyl-3-(1-methylethyl)benzenepropanal
- EC Number:
- 412-050-4
- EC Name:
- β-methyl-3-(1-methylethyl)benzenepropanal
- Cas Number:
- 125109-85-5
- Molecular formula:
- C13H18O
- IUPAC Name:
- 3-[3-(propan-2-yl)phenyl]butanal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Degree of purity: 95.4%
Physical condition: Liquid
Lot number: 8906-87
Test animals
- Species:
- rat
- Strain:
- other: Ibm: RORO (SPF)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of benzenepropanal, .beta.-methyl-3-(1-methylethyl)- is greater than 2000 mg/kg bodyweight in male and female rats.
- Executive summary:
Ten outbred stock, Ibm: RORO (SFP) animals (5 males and 5 females) were used. Animals were approximately 5-6 weeks old. Males weighed 107-131 grams and females weighed 112-119 grams. Animals wer housed individually in an air conditioned room. Room temperature was 20-24 C with relative humidity of 45-65% and an artificial light cycle of 12 hour darkness and 12 hours light per day. Food and water were available ad libitum except 18 hours prior to dosing where the animals were fasted. A single dose of test material in Standard Suspending Vehicle (SSV) was administered to each animal. Animals were observed for daily for 15 days for toxic signs including mortality and body weight changes. Bodyweights were recorded on days 0, 4, 7, 12 and 15. Gross necropsies were conducted on all animals
100 ml SSV contained: 5 grams sodium carboxymethyl cellulose of median viscosity, 4 ml Tween 80, 5 ml benzylalcohol pro analysi, 9 grams sodium-chloride pro analysi, aqua destillata ad 1000 ml.
The acute oral toxicity of benzenepropanal, .beta.-methyl-3-(1-methylethyl)- is greater than 2000 mg/kg bodyweight in male and female rats. No deaths occurred. No effect on bodyweight was observed. No findings at necropsy.
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