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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- 17-194T, Lot #: 300567-78-7
Composition: P,P-diethyl, monoester with 1,2 propanediol - 92.9%, CAS #2230512-72-6
Physical Description: Clear, transparent liquid
pH: Neutral to slightly acidic
Stability: Test substance was expected to be stable for the duration of testing.
Expiration Date: aug 30, 2022 - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
- Sampling method: When measuring the samples from this study, validity of calibration was controlled by measuring a QC sample (c = 4 mg/L).
- Sample storage conditions before analysis: no - Vehicle:
- no
- Details on test solutions:
- Good quality drinking water is used.
Table of analytical results of water is attached in illustration section below - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Danio rerio
- Strain: HAMILTON-BUCHANAN
- Source: The original animals are obtained in 2019 from the University Heidelberg and used for breeding and production of eggs.
- Age at study initiation (mean and range, SD): sexually immature young fish
- Length at study initiation (length definition, mean, range and SD): 1 – 2 cm
- Weight at study initiation (mean and range, SD):114.3 - 253.9 mg
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test): tap water, 2/12 hours, using neon tubes, Temp 23 °C
- Type and amount of food during acclimation: warm-water fish food
- Feeding frequency during acclimation: two times each working day;
- Health during acclimation (any mortality observed): not mention
FEEDING DURING TEST (as applicable) : 24 hours before the start of the test, the test fish were no longer fed.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 1.18 mmol/L
- Test temperature:
- 23 ± 2 °C
- pH:
- 8.12
- Dissolved oxygen:
- 7.5 mg/L
- Conductivity:
- 270 us/cm
- Nominal and measured concentrations:
- Nominal 100 mg/L
Measured 94.48 and 94.55 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:aquaria
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass aquaria, maximal volume 12 L, fill volume 7 L
- Aeration: accomplished with glass tubes
- Type of flow-through (e.g. peristaltic or proportional diluter): No, static
- Renewal rate of test solution (frequency/flow rate): No
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): No control
- No. of vessels per vehicle control (replicates): No vehicle used
- Biomass loading rate: 1 vessel, each containing 7 L test solution and 7 fish
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dilution water, supplied by the provider Verbandsgemeindewerke Maikammer.
- Total organic carbon: <0.5 mg/L
- Pesticides: < limit of detection
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 12/12 hours using neon tubes
- Light intensity: 400 – 800 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : death of the fish
TEST CONCENTRATIONS
- Spacing factor for test concentrations: no, limit test was performed
- Range finding study :In a non GLP pre-test no toxicity was observed against al-gae. In the SDS the EC50 against daphnia was stated as > 100 mg/L. Because of the low toxicity of the test item, this study was performed as a limit test at the concentra-tion 100 mg/L because in most cases the fish is the least sensitive test organism.
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- One valid experiment was performed. The toxicity against Danio rerio was tested using a static test design.
The study was performed as a limit test at the concentration 100 mg/L (nominal concentra-tion). In the treatment and in the control, no fish died or showed abnormal behavior.
At the beginning and at the end of the test, the content of the test item in the test solutions was determined using LC-MS -determination. The measured concentrations were 95 % of the nominal concentration at the beginning and 100 % at the end of the test.
LC50> 100 mg/L - Executive summary:
LC50> 100 mg/L
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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