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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-04-10 to 1990-05-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- EC Number:
- 405-520-5
- EC Name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- Cas Number:
- 95235-30-6
- Molecular formula:
- C15H16SO4
- IUPAC Name:
- 4-[4-(propan-2-yloxy)benzenesulfonyl]phenol
- Details on test material:
- - Name of test material (as cited in study report): D - 8
- Molecular formula: C15 H16 O4 S;
- Molecular weight: 292.4;
- Physical state: solid;
- Analytical purity: 99.94 %;
- Purity test date: not stated;
- Lot/batch No.: ME-685;
- Expiration date of the lot/batch: not stated;
- Stability under test conditions: stable at ambient temperature and conditions;
- Storage condition of test material: store in a cool dry place, protected from direct sunlight;
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited; Margate, Kent;
- Age at study initiation: approximately 7 to 9 weeks;
- Weight at study initiation: approximately 200 g;
- Fasting period before study: not indicated;
- Housing: individually in grid bottomed polypropylene cages;
- Diet: SQC R and M No. 1 expanded pelleted rodent diet ad libitum; Supplier: Special Diet Services; Witham, Essex;
- Water: mains drinking water from polypropylene bottles ad libitum;
- Acclimation period: eleven days before dosing
ENVIRONMENTAL CONDITIONS
- Temperature: 18 to 21 °C;
- Humidity: 41 - 58 % R.H.;
- Air changes: not stated;
- Photoperiod: 12 hrs dark/12 hrs light;
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Weighed aliquots of the test materials were applied to the clipped skin of the test animals in a dose level of 2000 mg/kg bw. The test material was moistened with water to assure intense contact with the skin of the animals. After spreading of the test material as even as possible on the skin of the test animals, the pplication site was covered with surgical gauze. The trunk of the test animals was then encircled by a length of elastic adhesive bandage to keep the material in contact withthe skin.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males; 5 females
- Control animals:
- no
- Details on study design:
- All animals were examined at approximately 30 minutes and 1, 2 and 4 hours after dosing and then daily for fourteen consecutive days. Any signs of toxicity or other effects were noted along with the time of onset and duration. Animals were weighed at weekly intervals.
- Statistics:
- NA
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- No mortalities were observed throughout the study.
- Clinical signs:
- other: No effects of treatment were observed throughout the study.
- Gross pathology:
- No significant abnormalities were found at necropsy.
- Other findings:
- No other findings were observed.
Any other information on results incl. tables
D-8 caused no apparent toxic effect and no mortality following the dermal administration to rats as a single dose of 2000 mg/kg. bw. No effects of treatment were observed throughout the study and no significant abnormalities were found at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- D-8 was tested for acute dermal toxicity in the rat by occlusive application of a single dose of 2000 mg/kg bw. No effects of treatment were observed throughout the study and no significant abnormalities were found at necropsy. It was concluded that the LD50 of the dermal toxicity is greater than 2000 mg/kg bw.
- Executive summary:
D-8 was tested for dermal toxicity in five male and five female rats. The test substance was applied in a single dose of 2000 mg/kg bw to the clipped skin of the animals under an occlusive dressing for 24 hours. After removing of the test article, animals were observed fourteen days for signs of treatment. No signs of toxicity were observed throughout the duration of the study. No significant abnormalities were detected at necropsy. The lethal dose on dermal application was determined to be greater than 2000 mg/kg bw.
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