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EC number: 442-390-9 | CAS number: 40573-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Dec 2001 to 14 Dec 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in accordance with good laboratory practice (GLP) regulations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Perfluormethoxypropylvinylether
- IUPAC Name:
- Perfluormethoxypropylvinylether
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Perfluormethoxypropylvinylether
- Substance type: Clear colorless liquid
- Physical state: Liquid
- Analytical purity: 98%
- Purity test date: 30 Jul 2000
- Lot/batch no.: Lot 3
- Expiration date of the lot/batch: 31 Dec 2002
- Storage condition of test material: Darkness at approximately 5 C in a refrigerator under nitrogen atmosphere
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH
- Age at study initiation: No data
- Weight at study initiation: 3.2-4.0 kg
- Housing: Individually in cages
- Diet (e.g. ad libitum): Ssniff K-H (V2333) ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period:1 week under study conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 04 Dec 2001 To: 14 Dec 2001
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3 females were dosed
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Eyes were washed with with isotonic saline 24 hours after starting the exposure to the test substance.
- Time after start of exposure: 24 hours.
SCORING SYSTEM: Cornea: 0-4, Iris: 0-2, Conjunctivae (Redness 0-3, Chemosis 0-4, Discharge 0-3).
TOOL USED TO ASSESS SCORE: UV lamp and fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- ca. 0 - ca. 0.33
- Reversibility:
- fully reversible
- Remarks on result:
- other: Scale 4
- Irritant / corrosive response data:
- A conjunctivae redness score of 1 was observed in a single animal at the 24 hour observation period and had resolved by the 48 hour observation. No other scores were noted at any other animals at any other point during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, the test material is not an eye irritant.
- Executive summary:
The eye irritation potential of the test material was determined in New Zealand White rabbits (3, female). The study was conducted according to OECD GLP (1999). The test method was based on OECD 405 (1987), EEC Method B.5 (1992), and US EPA OPPTS 870.2400 (1998). 0.1 mL of the test material was instilled in the conjunctival sac of the left eye of each animal. The right eye of each animal was left untreated to serve as a control. 24 hours after administration the treated eyes were washed thoroughly with isotonic saline. The eyes were examined at 1, 24, 48, and 72 hours. At 24 and 72 hours, the eyes were further examined for corneal lesions under UV light after instillation of one drop of a 0.01% fluorescein-sodium solution. The cornea (0-4), Iris (0-2), and Conjunctivae (Redness: 0-3, Chemosis: 0-4, and Discharge; 0-3) were examined and scored appropriately at each of the observation period. A conjunctivae redness score of 1 was observed in a single animal at the 24 hour observation period and had resolved by the 48 hour observation. No other scores were noted at any other animals at any other point during the study. Based on the results of the study, the test material is not an eye irritant.
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