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Diss Factsheets
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EC number: 827-581-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- > 347 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 30 °C
- pH:
- 6.31
- Details on results:
- Initial testing indicated that the sample was insoluble in water, since residual particulates were observed. However, as the substance is a complex mixture th testing was repeated with a focused on the main constituent components.
Saturated solutions were prepared (in triplicate) by transferring 25.0 g of the test material, followed by water 25.0 g into 100 mL screw topped conical flasks.The three flasks were transferred into a shaker set at 30°C and shaken at 150 rpm. The initial preliminary analysis indicated a significantly lower value due to the presence of a minor component in the test material that was less soluble. The values given for the preliminary analysis were based on a sample following HPLC analysis. It was not possible to prepare a solution at 3-5 times the saturation value as stated in the test procedure, as this would have resulted in a semi-solid / paste. Consequently a 50 % w/w sample was prepared. Following the Day 1 sample shaking and equilibration periods, the sample became a semi-mobile paste. The Day 1 sample was centrifuged for 1 hour, after which no separation of a solid and liquid component was observed. It was not possible to pass the semi mobile paste through a filter prior to analysis by HPLC. Therefore a single sample would be prepared at the highest concentration where a solution / separation was previously achieved. A 33 % w/w sample was prepared, shaken for 3 days at 30°C and allowed to equilibrate for 48 hours prior to analysis. The sample was centrifuged for 45 minutes. This resulted in an opaque supernatant with approximately 5-10 % of a white solid in the base of the centrifuge tube. The sample was
analysed and found to be soluble at 347.1 g/L. - Conclusions:
- The sample was found to be soluble at 347.1 g/L.
The solubility reported is based upon the amount of active ingredient that was dissolved in water and not based on the product as a whole. The solubility of the product as a whole would be significantly less due to the relative insolubility of a minor component present in the test material. - Executive summary:
Initial testing indicated that the sample was insoluble in water, since residual particulates were observed. However, as the substance is a complex mixture th testing was repeated with a focused on the main constituent components.
Saturated solutions were prepared (in triplicate) by transferring 25.0 g of the test material, followed by water 25.0 g into 100 mL screw topped conical flasks.The three flasks were transferred into a shaker set at 30°C and shaken at 150 rpm. The initial preliminary analysis indicated a significantly lower value due to the presence of a minor component in the test material that was less soluble. The values given for the preliminary analysis were based on a sample following HPLC analysis. It was not possible to prepare a solution at 3-5 times the saturation value as stated in the test procedure, as this would have resulted in a semi-solid / paste. Consequently a 50 % w/w sample was prepared. Following the Day 1 sample shaking and equilibration periods, the sample became a semi-mobile paste. The Day 1 sample was centrifuged for 1 hour, after which no separation of a solid and liquid component was observed. It was not possible to pass the semi mobile paste through a filter prior to analysis by HPLC. Therefore a single sample would be prepared at the highest concentration where a solution / separation was previously achieved. A 33 % w/w sample was prepared, shaken for 3 days at 30°C and allowed to equilibrate for 48 hours prior to analysis. The sample was centrifuged for 45 minutes. This resulted in an opaque supernatant with approximately 5-10 % of a white solid in the base of the centrifuge tube. The sample was
analysed and found to be soluble at 347.1 g/L.
The solubility reported is based upon the amount of active ingredient that was dissolved in water and not based on the product as a whole. The solubility of the product as a whole would be significantly less due to the relative insolubility of a minor component present in the test material.
Reference
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 347 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.