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EC number: 915-932-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 April 1990 - 5 June 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of dipotassium 3,3'-sulphonylbis(benzenesulphonate) and potassium 3-(phenylsulphonyl)benzenesulphonate
- EC Number:
- 915-932-1
- Molecular formula:
- Reaction mass of C12H8O8S3.2K and C12H9O5S2.K
- IUPAC Name:
- Reaction mass of dipotassium 3,3'-sulphonylbis(benzenesulphonate) and potassium 3-(phenylsulphonyl)benzenesulphonate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Test substance: Additive VP KU 1-1909
Lot#: DZA-UER -8919598-A
Manufacturer: Bayer AG, Leverkusen
Purity: 86.5% (see annex, appendix.3)
Identity/Stability: guaranteed for the study period
Storage: room temp, darkness
CAS #: 63316-43-8
Molecular weight: 336 g/mol
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino HC:NZW
- Details on test animals or tissues and environmental conditions:
- Prior to the study, rabbits were individually housed in stainless steel cages with perforated bases, uder standardized conventional coditions. Excrement trays beneath the cages contained low-dust (wood) bedding. Bedding was regularly spot checked for contaminants at the instance of the Department of Laboratory Animal Services, and changed at leased twice weekly.
Room temp: 20 +/- 3 Celsius
Humidity: 50%
Light/Dark cycle: 12h, artificial illumination
Air exchange rate: ~10 times per hour
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- ca. 70 mg
- Duration of treatment / exposure:
- eyelids were gently held shut for aprox. one second and were not rinsed for 24 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 6 rabbits used
- Details on study design:
- Eye irritation was scored and recorded at the 1 hr, 24 hrs, 48 hrs, 72 hrs, 8 days, 14 days, and 21 days after administation. The signs of cornea (opacity and area affected), iris (hyperaemia, reaction to light), conjunctivae (erythema, chemosis) and discharge were recorded as described by DRAIZE, and the aqueous humour as described by MCDONALD and SHADDUCK. In addition any serious lesions or toxic effects other than ocular ones were recorded. The examinations of cornea, iris, and aqueous humur were facilitated using optical insturments. To define epithelial damage, one drop of a 1% fluoresceom solution was applied to the corneal surface 24 hours after administration of the test substance; where positibe effects were recorded this was repeated at the later observation times. The eye was then rinsed with saline to remove excess and nonabsorbed fluorescein. Evaluation was performed by means of ultraviolet illumination in a darkened room and diffuse white illumination, according to MCDONALD and SHADDUCK.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 2 thru 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not Applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: 2 thru 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not Applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1 thru 3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 4 thru 6
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1 thru 6
- Time point:
- 24/48/72 h
- Score:
- <= 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Only mild signs of eye irritation, which were fully reversible withing 14 days, were observed.
- Other effects:
- None reported.
Any other information on results incl. tables
Only mild signs of eye irritation, which were fully reversible withing 14 days, were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was determined to be slightly to moderately irritating the the eye.
- Executive summary:
In a GLP guidline study conducated according to OECD guideline 405, six rabbits were tested for irritation to the eye. One animal showed a transient moderate opacity exlusively located at the inferior section of the cornea. In this rabbit the iris was temporatily affected. The signes proved to be fully reversable thus considered to be slightly to moderately irritating to the eye. All other animals showed only mild signs of eye irriations. Based on these results, the substance does not meet the GHS criteria for classification as causing serious eye damage (Category 1), a serious eye irritant (Category 2A), or mild eye irritant (Category 2B).
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