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Diss Factsheets
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EC number: 947-589-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Read across study
- Justification for type of information:
- Refer to the section 13 of the IUCLID dataset for details on the read across justification. The toxicity to microorganisms study with the read across substance is considered sufficient to fulfil the information requirements.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive 88/302/EEC Activated sludge: Assessment of the respiration inhibition
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source: activated sludge from laboratory wastewater treatment plant treating municipal sewage (Husmann 1-3 (8:2))
- Initial biomass concentration: 5 g/L dry matter in stock vessel; 1 g/L dry matter in test assay - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 min
- Test temperature:
- Ambient temperature
- Nominal and measured concentrations:
- Nominal: 10, 100, 1000 mg/L
- Details on test conditions:
- Test system:
- Test vessel: no further details
- Material, size, headspace, fill volume:
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
Effect parameters observed (with observation intervals if applicable) :
- Respiration: 30 min
Test concentrations:
- Spacing factor for test concentrations: 10 - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC20 = 8 mg/L; EC50 = about 18 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 30 min EC10 of the substance in activated sludge was determined to be >1000 mg/L.
- Executive summary:
A study was conducted to determine the toxicity of the read-across substance 2,2’-iminodiethanol (diethanolamine) to microorganisms according to OECD Guideline 209 and EC Directive 88/302/EEC. Activated sludge of a predominantly domestic sewage was exposed to the test substance at nominal concentrations of 10, 100 and 1000 mg/L for 30 minutes. A positive control (3,5-dichlorophenol) was included in the experiment. The inhibition of total respiration was monitored throughout the study. Under the study conditions, the nominal 30 min EC10 of the substance in activated sludge was determined to be >1000 mg/L (BASF AG, 1992).
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Read across study
- Justification for type of information:
- Refer to the section 13 of the IUCLID dataset for details on the read across justification. The toxicity to microorganisms study with the read across substance is considered sufficient to fulfil the information requirements.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- yes
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Up to 1 g/L cloudy solution
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Activated sludge from the municipal STP Hildesheim
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 21°C
- Nominal and measured concentrations:
- 0, 100, 180, 320, 580 and 1000 mg/L (nominal) + control
- Reference substance (positive control):
- yes
- Remarks:
- Copper(II)sulphate-pentahydrate.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- The positive control gave a 3h EC50 respiration inhibition of 47 and 55%.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 3 h EC50 of the substance in activated sludge was determined to be >1000 mg/L.
- Executive summary:
A study was conducted to determine the toxicity of the read-across substance Phosphoric acid, dodecyl ester, potassium salt (mono- C12 PSE, K+) to microorganisms in activated sludge according to OECD Guideline 209 and EU Method C.11, in compliance with GLP. Activated sludge from a domestic sewage treatment plant was exposed to an aqueous dispersion of the test substance at nominal concentrations of 0, 100, 180, 320, 280 and 1000 mg/L. The rate of respiration was determined after 3 h contact and compared to data for the control. Copper(II)sulphate-pentahydrate was used as positive control and gave a 3 h EC50 (respiration inhibition of 47 and 55%). The 3 h EC20 and EC80 for the test substance were greater than 1000 mg/L. Under the study conditions, the nominal 3 h EC50 of the substance in activated sludge was determined to be >1000 mg/L (Noack, 1991).
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
A study was conducted to determine the toxicity of the read-across substance Phosphoric acid, dodecyl ester, potassium salt (mono- C12 PSE, K+) to microorganisms in activated sludge according to OECD Guideline 209 and EU Method C.11, in compliance with GLP. Activated sludge from a domestic sewage treatment plant was exposed to an aqueous dispersion of the test substance at nominal concentrations of 0, 100, 180, 320, 280 and 1000 mg/L. The rate of respiration was determined after 3 h contact and compared to data for the control. Copper(II)sulphate-pentahydrate was used as positive control and gave a 3 h EC50 (respiration inhibition of 47 and 55%). The 3 h EC20 and EC80 for the test substance were greater than 1000 mg/L. Under the study conditions, the nominal 3 h EC50 of the substance in activated sludge was determined to be >1000 mg/L (Noack, 1991).
A study was conducted to determine the toxicity of the read-across substance 2,2’-iminodiethanol (diethanolamine) to microorganisms according to OECD Guideline 209 and EC Directive 88/302/EEC. Activated sludge of a predominantly domestic sewage was exposed to the test substance at nominal concentrations of 10, 100 and 1000 mg/L for 30 minutes. A positive control (3,5-dichlorophenol) was included in the experiment. The inhibition of total respiration was monitored throughout the study. Under the study conditions, the nominal 30 min EC10 of the substance in activated sludge was determined to be >1000 mg/L (BASF AG, 1992).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.