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EC number: 288-914-8 | CAS number: 85940-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 August - 26 September, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 19 March 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- Principles of method if other than guideline:
- The solubility of the test item is below 0.01 g/L, so the column elution method should be applied according to the guideline. However, column elution method is not feasible with this test item, because coating of the support material is not possible due to the low solubility of the test item in any solvent. Therefore, the flask method was applied.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Remarks:
- shake flask method
- Specific details on test material used for the study:
- Expiry date: September 12, 2021
- Water solubility:
- >= 1.69 - <= 1.73 mg/L
- Conc. based on:
- act. ingr. (dissolved fraction)
- Loading of aqueous phase:
- 5 000 mg/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- >= 4.16 - <= 4.19
- Remarks on result:
- other: Mean with the 95% confidence intervals 1.71 ± 0.02 mg/L
- Water solubility:
- >= 1.34 - <= 1.96 mg/L
- Conc. based on:
- act. ingr. (dissolved fraction)
- Loading of aqueous phase:
- 5 000 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 20 °C
- pH:
- 4.18
- Remarks on result:
- other: Mean with the 95% confidence intervals 1.65 ± 0.31mg/L.
- Water solubility:
- >= 1.6 - <= 1.778 mg/L
- Conc. based on:
- act. ingr. (dissolved fraction)
- Loading of aqueous phase:
- 5 000 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 4.17 - <= 4.22
- Remarks on result:
- other: Mean with the 95% confidence intervals 1.69 ± 0.09 mg/L
- Key result
- Water solubility:
- 1.68 mg/L
- Conc. based on:
- act. ingr.
- Loading of aqueous phase:
- 5 000 mg/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 4.2
- Details on results:
- Results of the test and measured concentrations of test item are presented in the following table. The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines
- Conclusions:
- In conclusion the water solubility of the test item was determined to be 1.68 ± 0.07 mg/L (95% confidence interval) at 20 °C ± 1 °C using the shake-flask method for the performance.
- Executive summary:
The water solubility of the test item was assessed according to OECD Guideline 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions. The solubility of the test item is below 10 -2g/L, so the column elution method should be applied according to the guideline. However, column elution method is not feasible with this test item, because coating of the support material is not possible due to the low solubility of the test item in any solvent. Therefore, the shake-flask method was applied. In result, the water solubility of the test item was determined to be 1.68 +/- 0.07 (95% confidence interval) at 20 °C +/- 1 °C.
Reference
Results of the Method Validation
Measurement repeatability |
CV% ≤ 0.5 % |
Repeatability of the Preparation (n=5) |
CV%< 2 % |
Linear range |
0.2 - 20 µg/mL |
Correlation coefficients |
> 0.999 |
Limit of Quantification |
0.2 µg/mL |
Limit of Detection |
0.1 µg/mL |
Recovery from ISO medium |
101 % |
Recovery from20X AAPmedium |
≥ 99 % |
Recovery from ultra-pure water |
102 % |
Accuracy(samples used for calibration) |
≤6 % |
Precision |
≤ 6 % (9 % at LOQ) |
Stability of the test item in ISO medium at the temperature 18-22 °C for 2 days |
46 % at the test conditions |
Stability of the test item in 20X AAP medium at the temperature 22-26 °C for 7 days |
<LOD |
Stock solution stability (1 mg/ml), after dissolution, dye complexation and color development |
stable |
Results of the determination of test item concentrations
Sampling time |
Measured concentration of test item (mg/L ) |
Measured pH |
|
Test vessels |
Mean withthe 95% confidence intervals |
||
After 24h |
1.72 |
1.71 ± 0.02 |
4.17 |
1.70 |
4.16 |
||
1.71 |
4.19 |
||
After 48h |
1.51 |
1.65 ± 0.31 |
4.18 |
1.69 |
4.18 |
||
1.76 |
4.18 |
Results of the determination of test item concentrations (continued)
Sampling time |
Measured concentration of test item (mg/L ) |
Measured pH |
|||
Test vessels |
Mean withthe 95% confidence intervals |
||||
After 72h |
1.65 |
1.69 ± 0.09 |
4.18 |
||
1.72 |
4.22 |
||||
1.71 |
4.17 |
||||
Solubility ofthe test item (mg/L) |
1.68 ± 0.07 |
- |
|||
RSD% |
2 |
- |
|||
Ultra-pure water |
< LOQ |
5.96-5.98 |
Description of key information
The water solubility of the substance was determined to be 1.68 ± 0.07 mg/L (95% confidence interval) at 20 °C ± 1 °C using the shake-flask method for the performance.
Key value for chemical safety assessment
- Water solubility:
- 1.68 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was assessed according to OECD Guideline 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions. The shake-flask method was applied. The water solubility of the test item was determined to be 1.68 ± 0.07 (95% confidence interval) at 20 °C ± 1 °C
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