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EC number: 272-716-3 | CAS number: 68909-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 13 Nov 1978 and 16 Nov 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Pre GLP, performed according to US D.O.T standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US D.O.T. requirements
- Version / remarks:
- according to Section l73.240 (a) (1) Title 49 CFR and Section 1500.41 Title 16 CFR
- Deviations:
- no
- Principles of method if other than guideline:
- - Principle of test: For the D.O.T study. The methods employed in the testing, evaluation and scoring (according to Draize) of the results are similar to OECD 404. 0.5 g material is applied to the intact and abraded skin of 6 rabbits for 4 hours under closed conditions, with readings after end of exposure and at 24 and 48 hours..
For the irritation study however, exposure durtation is 24 hours, and readings are done after exposure (= 24 hours) and again at 72 hours after start of exposure.
- Parameters observed are Erythema and Eschar Formation, and Edema. - GLP compliance:
- not specified
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- Morwet B
- IUPAC Name:
- Morwet B
- Test material form:
- solid: granular
- Details on test material:
- Material: Petrochemicals Company, Inc. - Morwet B
Constituent 1
- Specific details on test material used for the study:
- Commercial product
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- A group of six albino rabbits were clipped over a wide area. One side of the animals' backs was abraded at two sites with a lancet sufficiently deep to penetrate the stratum corneum but not enter the derma to produce bleeding. The skin on the other side was allowed to remain intact.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped, and either intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- A 0.5 gm portion of the material was applied to two abraded and two intact skin sites on the same rabbit. Gauze patches were then placed over the treated areas and an impervious material was wrapped snuggly around the trunks of the animals to hold the patches in place.
- Duration of treatment / exposure:
- 4 hours (D.O.T. corrosion) and 24 hours (primary irritation)
- Observation period:
- Up to 48 hours (D.O.T. corrosion) and 72 hours (primary irritation)
- Number of animals:
- 6
- Details on study design:
- The primary skin irritation study was conducted on the intact and abraded skin sites adjacent to each other towards the head end of the animal while the D.O.T. study was conducted on the intact and abraded skin sites adjacent to each other towards the tail end of the animal.
The wrappings were removed at the end of a four hour period for the D.O.T. study and the treated areas were examined. Readings were also made after twenty-four and forty-eight hours. The Draize method of scoring was employed.
The wrappings were removed at the end of a twenty-four hour period for the primary skin irritation study and the treated areas were examined. Readings were also made after seventy-two hours. The Draize method of scoring was employed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4 hour exposure on intact (non-abraded) skin
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24 h
- Score:
- 0.33
- Max. score:
- 1
- Remarks on result:
- probability of weak irritation
- Remarks:
- grade 1 eythema in 2/6 animals
- Irritation parameter:
- erythema score
- Remarks:
- 4 hour exposure on intact (non-abraded) skin
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 48 hour
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 4 hour exposure on intact (non-abraded) skin
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- The 4 hour exposure did not result to formation of edema in any of the 6 animals at any of the time points. Erythema grade 1 was only visible after 24 hours on the skin of 2/6 animals following application on the intact skin. Application to the abraded skin only resulted to grade 1 erythema in 5/6 animals immediately after 4-hour application, but no erythema was observed at any of the other time points.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following application on the intact and abraded skin of 6 animals under occlusive conditions for 4 hours was practically non-rritating. Expsoures for 24 hours resulkted to mild irritation.
- Executive summary:
Morwet B (Naphthalenesulfonic acid, methyl, butyl, sodium salt) was evaluated for dermal irritation and corrosion in a D.O.T. skin corrosion and a primary skin irritation study involving exposure to the intact and abraded skin of 6 albino rabbits.
Skin areas were clipped over a wide area. One side of the animals' backs was abraded at two sites with a lancet sufficiently deep to penetrate the stratum corneum but not enter the derma to produce bleeding. The skin on the other side was allowed to remain intact.
A 0.5 gram portion of the material was applied to two abraded and two intact skin sites on the same rabbit. Gauze patches were then placed over the treated areas and an impervious material was wrapped snuggly around the trunks of the animals to hold the patches in place.
The D.O.T. study was conducted on the intact and abraded skin sites adjacent to each other towards the tail end of the animal. The wrappings were removed at the end of a four hour period and the treated areas were examined. Readings were also made after twenty-four and forty-eight hours. The Draize method of scoring was employed.
The primary skin irritation study was conducted on the intact and abraded skin sites adjacent to each other towards the head end of the animal. The wrappings were removed at the end of a twenty-four hour period for the primary skin irritation study and the treated areas were examined. Readings were also made after seventy-two hours. The Draize method of scoring was employed.
Results:
The primary skin irritation study: Following 24 hour exposure to the intact skin under occlusive conditions resulted to only mild irritation. The erythema score was 1 or 2 in all animals at the 24 hour reading with a 1, 2 or 3 grade edema. At 72 hours only two animals still showed some signs of irritation with a grade 1 erythema and a grade 1 or 2 edema.
The results from 24 hour exposure to the abraded skin showed slightly higher reaction.
Average score Intact skin following 24 hour exposure:
- 24 h reading: erythema: 1.83; edema: 2.00
- 72 h reading: erythema: 0.33; edema: 0.50
Average score Intact skin following 24 hour exposure:
- 24 h reading: erythema: 1.83; edema: 2.17
- 72 h reading: erythema: 1.00; edema: 1.17
D.O.T. study for skin corrosion: The 4 hour exposure did not result to formation of edema in any of the 6 animals at any of the time points. Erythema grade 1 was only visible after 24 hours on the skin of 2/6 animals following application on the intact skin. Application to the abraded skin only resulted to grade 1 erythema in 5/6 animals immediately after 4-hour application, but no erythema was observed at any of the other time points.
Average score Intact skin following 4 hour exposure:
- 4 h reading: erythema: 0; edema: 0
- 24 h reading: erythema: 0.33; edema: 0
- 48 h reading: erythema: 0; edema: 0
Average score Intact skin following 4 hour exposure:
- 4 h reading: erythema: 0.83; edema: 0
- 24 h reading: erythema: 0; edema: 0
- 48 h reading: erythema: 0; edema: 0
The results from the 4-hour exposure can be used for GHS classification, and indicate that Morwet B does not need to be classified for skin erritation.
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