Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-317-6 | CAS number: 57-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-Sep-2017 to 09-Mar-2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,1-trichloro-2-methyl-2-propanol hemihydrate
- Cas Number:
- 6001-64-5
- Molecular formula:
- C4H7Cl3O H2O
- IUPAC Name:
- 1,1,1-trichloro-2-methyl-2-propanol hemihydrate
- Test material form:
- solid: crystalline
- Details on test material:
- transparent and crystalline solid at ambient temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- GC-MS
- Details on sampling:
- Specimens were drawn from freshly prepared treatments and those incubated for 48 hrs. The supporting analysis of the specimens could not be performed on the same day of collection of the specimens. Therefore, all specimens from freshly prepared test solutions and those incubated for 48 hrs were stored deep-frozen at <= -18°C in glass bottles and analysed after thawing.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS (clone 5) of SGS INSTITUT FRESENIUS Iabaratory bred (derived from Dr. M. Bergtold, BASF, D-67117 Limburgerhof) was used for the test. The cultivation of the daphnia is performed in a way that the animals are transferred in new test medium at an interval of 1 to 3 days followed by feeding with Desmodesmus subspicatus- and/or Ch/ore//a-cells. Daphnia used for the test are not older than 24hr. Therefore, in every case, daphnias are transferred into fresh medium one day before starting of the daphnia test in order to get daphnia for the test younger than 24hr. During the test the daphnia were not fed.
Study design
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20 ± 1°C
- pH:
- 8.2 ± 0.4
- Dissolved oxygen:
- 8.2 ± 0.4 mg/L
- Nominal and measured concentrations:
- 0, 40, 60, 90, 135 and 202.5 mg/L
As a result of the supporting analyse it can be stated that the results of the biological part should be based on the nominal concentrations applied because the necessary stability of ~ 80% could be shown. - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 d
- Dose descriptor:
- EC10
- Effect conc.:
- 74.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 110.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- ln order to verify the sensitivity of the test system towards toxic items the effect of potassium dichromate towards different animals of this breed was tested prior to beginning of the test. The value of the EC50 (24h) in this period of time was at 0.97 mg/L potassium dichromate. This value is in accordance with the recommended range given in OECD Guideline 202 (Daphnia sp., Acute Immobilisation Test) being 0.6 to 2.1 mg/L potassium dichromate given in OECD Guideline 202 (Daphnia sp., Acute Immobilisation Test) and the range given in the study plan.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test is considered valid as all conditions for validity were met.
- Executive summary:
Chlorobutanol Hemihydrate was tested for acute toxicity towards daphnia according to OECD Test Guideline 202 (version dated 13-Apr-2004). ln order to investigate the influence of the test item towards the daphnia, the swimming behaviour of the animals was recorded. Under the conditions used for the test, there was an immobilisation of the daphnia at concentrations >60 mg/L. As a conclusion of the analytical part of this study, it can be stated that the concentrations Chlorobutanol Hemihydrate remained sufficiently stable during incubation of 48hrs. As a result of the supporting analyse it can be stated that the results of the biological part should be based on the nominal concentrations applied because the recoveries of the nominal concentrations were all >80%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.