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Diss Factsheets
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EC number: 915-680-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- EC Number:
- 915-680-2
- Cas Number:
- 170836-68-7
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The substance was administrated by gavage to 15 male and 15 female rats per group for 90 consecutive days at dose levels of 500, 1500 and 3000 mg/kg.A fourth group of rats formed the control.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 15
- Details on study design:
- Potential toxic effects were evaluated in terms of the following: Appearance and behavior, mortality, body weight, Food consumption,Efficiency of food utilization, Hematology, Clinical Chemistry, Urinalysis, Necropsy examination ( including weight of 9 organs) and Histologic examination ( of up to 25 tissues in each of the high and control groups).
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, non-treatment-related
- Description (incidence and severity):
- With reference to body weight, male rats from the 3 000 mg/kg group showed significantly less body weight gain than the other 3 groups at weeks 9,12 and 13.
- Food consumption and compound intake (if feeding study):
- effects observed, non-treatment-related
- Description (incidence and severity):
- Statistical analysis of food consumption values revealed that male rats from the 3 000 mg/kg group showed significantly less food consumption than the control group at week 5 and significantly less food consumption than the other 3 groups at week 7. For female rats, the following significance was observed: at week 5 the control group consumed significantly greater amounts than the other 3 groups; at week 8 the control group consumed significantly less than the 1500 and 3000 mg /kg groups and at week 12 the 1500 mg/kg group consumed significantly less than the other 3 groups. No consistent significant differences were therefore established for food consummation
- Clinical biochemistry findings:
- not specified
- Description (incidence and severity):
- Clinical chemistry determinations revealed that pre-test for lactic acid dehydrogenase were elevated for all groups and this evaluation was probably attributed to hemolysis. At 90 days, clinical chemistry values for test animals were comparable to control.
- Urinalysis findings:
- no effects observed
- Description (incidence and severity):
- Urinalysis determinations gave no evidence of any compound related effects
- Behaviour (functional findings):
- no effects observed
- Histopathological findings: neoplastic:
- effects observed, non-treatment-related
- Description (incidence and severity):
- Histopathological evaluation revealed the appearance of fatty degeneration and cloudy swelling of the liver in all dose levels. However, this finding was reproduced in the test animals with a somewhat greater incidence of fatty degeneration at the 1500 mg/kg level. In the 500 mg/kg dose, the degree of change was similar to the controls. In the 3 000 mg/kg dose, the incidence was moderately increased over the control, but not to the extent seen at the 1500 mg/kg dose.
Effect levels
- Key result
- Dose descriptor:
- other: NOAC
- Effect level:
- ca. 3 000 other: mg/kg
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- behaviour (functional findings)
- body weight and weight gain
- clinical biochemistry
- food consumption and compound intake
Target system / organ toxicity
- Key result
- Critical effects observed:
- no
- System:
- other:
Applicant's summary and conclusion
- Conclusions:
- The findings at 1500 and 3000 mg/kg are not statistically definite and it is concluded that the substance does not produce noteworthy toxic effects by comparison between control and test animals. The NOAC is therefore considered to be 3000 mg/kg.
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