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EC number: 500-232-7 | CAS number: 68815-56-5 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- March 24, 2004 - May 10, 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Substance was tested as dissolved fraction only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Alcohols, C10-16, ethoxylated, sulfosuccinates, disodium salts
- EC Number:
- 500-232-7
- EC Name:
- Alcohols, C10-16, ethoxylated, sulfosuccinates, disodium salts
- Cas Number:
- 68815-56-5
- Molecular formula:
- not applicable to UVCB
- IUPAC Name:
- Alcohols, C10-16, ethoxylated, sulfosuccinates, disodium salts
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Remarks:
- Crl: WI (Han)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan SLC, Inc.
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 4 weeks
- Fasting period before study: 4 hours fasting prior to the admnistration
- Housing: Five test animals each were housed in a polycarbonate cage and bred in a breeding room.
- Diet: ad libitum
- Water: tap water, ad libitum
- Acclimation period: approximately 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2
- Photoperiod (hrs dark / hrs light): 12 /12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 w/v% hydroxypropyl methyl cellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100 mg/mL
- Amount of vehicle: 20 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 females per group
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: before administration, and 7 and 14 days after administration
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsies - Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat. (dissolved fraction)
- Remarks:
- 27% solution
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 540 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No deaths were found during the observation period.
- Clinical signs:
- other: In the sample group, diarrhea was observed in 2 animals approximately 4 hours after administration, which was resolved by Day 1 after administration with no other abnormalities reported subsequently. In the other animals, no abnormalities were found durin
- Gross pathology:
- No abnormalities identified in any of the test animals.
Any other information on results incl. tables
Table-1 Body weight change
Group |
Before administration |
After administration (day) |
|
7 |
14 |
||
Sample group |
26.5±1.4 (5) |
28.9±1.3 (5) |
31.0±2.1 (5) |
Control groups |
26.3±1.0 (5) |
28.7±0.9 (5) |
31.2±0.7 (5) |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The acute oral LD50 of the test substance in female mice is >2000 mg/kg bw. As the test substance was a 27% solution of registration substance, the recalucated acute oral LD50 of the test substance in female mice is > 540 mg/kg bw.
- Executive summary:
The acute oral LD50 for the test substance was determined in an OECD Guideline 420 test. Two groups, each of five female mice were successively dosed with 2000 mg/kg of test substance in 0.5 w/v% hydroxypropyl methyl cellulose (HPMC) and the solvent control (0.5 w/v% HPMC). All animals surrvived until the end of the study. The acute oral LD50 of the test substance in female mice is > 2000 mg/kg bw. As the test substance was a 27% solution of registration substance, the recalucated acute oral LD50 of the test substance in female mice is > 540 mg/kg bw.
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