Registration Dossier
Registration Dossier
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EC number: 947-744-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no studies available in which the toxic kinetic properties of Hostacerin DGSB are investigated. Thus a kinetic assessment based on available data is provided.
Test substance is a yellow wax at room temperature. The vapor pressure of the test substance registered is 3.5E-6 hPa and the log Pow is 2.3 at 23°C / pH 6.7 - 7.0. The test substance is of low systemic toxicity which could be determined in two subacute studies (i.e. Repeated Dose Toxicity Study in Rats and a Reproduction/Developmental Toxicity Screening Test in rats) where a NOAEL of 1000 mg/kg bw/d was determined for each study. The test substance is not a skin sensitizer nor a skin irritant and is of no toxicity after acute dermal application where an LD50 of greater than 2000 mg/kg was determined. After oral ingestion the substance can enzymatically be divided in its fatty acids and the ethoxylated polyglycerol. The liberated fatty acids will be incorporated into the fatty acid metabolism.
The substance is likely to be of low bioavailability by inhalation due to the low vapor pressure.
The substance is likely to be of low bioavailability by dermal route due to the waxy properties (low water solubility, aggregate property). The assumed low bioavailability is in line with the low (no) toxicity observed in an acute oral toxicity study (LD 50 oral >10000 mg/kg bw) and the subacute repeated oral dose studies in rats.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies available in which the toxicokinetic properties of Hostacerin DGSB are investigated. Thus a kinetic assessement based on available data is provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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