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Diss Factsheets
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EC number: 225-202-8 | CAS number: 4712-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study following current guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- 1 minor deviation; the omission of ammonium chloride from the medium to prevent oxygen consumption due to nitrification
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Test material form:
- other: liquid
- Details on test material:
- Test material supplied by Addivant USA LLC
Batch: MW4K25B801
>99% purity
<1% phenol impurity
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- Obtained from wastewater treatment plant Nieuwgraaf in Duiven, Netherlands The plant treats predominantly domestic wastewater. The activated sludge was preconditioned to reduce the endogenous respiration rates by aeration for one week.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- formulation
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The Closed Bottle test was performed according to the study plan. The study plan was developed from ISO Test Guidelines (1994). Use was made of 10 bottles containing only inoculum, 10 bottles containing inoculum, silica gel and test substance, 10 bottles containing inoculum, and silica gel, and 6 bottles containing sodium acetate, and inoculum. The concentrations of the test substance, and sodium acetate in the bottles were 2.0, and 6.7 mg/L, respectively. Each of the prepared solutions was dispensed into the respective group of BOD bottles so that all bottles were completely filled without air bubbles. The zero time bottles were immediately analyzed for dissolved oxygen using an oxygen electrode. The remaining bottles were closed and incubated in the dark. Two duplicate bottles of all series were withdrawn for analyses of the dissolved oxygen concentration at day 7, 14, 21, and 28.
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Preliminary study:
- Results of a preliminary study lead to the use of activated sludge with silica carrier agent.
- Test performance:
- Triphenyl phosphite is biodegraded by 84% at day 28 in the Closed Bottle tes). Over 60% biodegradation was achieved after approximately 6 days immediately
following the attainment of 10% biodegradation. The test substance therefore fulfilled the time window criterion for ready biodegradable substances. Hence, the test substance is classified as readily biodegradable.
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 70
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 75
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 80
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 84
- Sampling time:
- 28 d
Any other information on results incl. tables
Theoretical oxygen demand (ThOD)
The calculated theoretical oxygen demand (ThOD) of triphenyl phosphite is 2.2 mg/mg. The ThOD of sodium acetate is 0.8 mg/mg
Toxicity
Inhibition of the degradation of a well-degradable compound, e.g. sodium acetate by the test substance in the Closed Bottle test was not determined because possible toxicity of triphenyl phosphite to microorganisms degrading acetate is not relevant. Inhibition of the endogenous respiration of the inoculum by the test substance at day 7 was not detected . Therefore, no inhibition of the biodegradation due to the "high" initial test substance concentration is expected.
Test conditions
The pH of the media was 7.3 at the start of the test. The pH of the medium at day 28 was 7.3 (both controls), and 7.1 (test). Temperatures were within the prescribed temperature range of 22 to 24°C.
Validity of the test
The validity of the test is demonstrated by an endogenous respiration of 0.9 mg/L at day 28. Furthermore, the differences of the replicate values at day 28 were less than 20%. The biodegradation percentage of the reference compound, sodium acetate, at day 14 was 83%. Finally, the validity of the test is shown by oxygen concentrations >0.5 mg/L in all bottles during the test period.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The validity of the test is demonstrated by an endogenous respiration of 0.9 mg/L at day 28 (Table I). Furthermore, the differences of the replicate values at day 28 were less than 20%. The biodegradation percentage of the reference compound, sodium aceta
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The results of the study show TPP is readily biodegradable meeting both the overall and 10-window criteria.
- Executive summary:
TPP was 84% biodegradable in a 28 -day ready biodegradation study using OECD 301D (closed bottle test). The results also passed the 10 -day window of 60% biodegradation during the first week of the study. TPP will be classified as readily biodegradable based on these results.
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