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EC number: 216-703-2 | CAS number: 1644-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Surface tension
Administrative data
- Endpoint:
- surface tension
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because water solubility is below 1 mg/L at 20°C
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 21, 2016 to November 9, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Naqme of the test substance: MTDID 15856
- Source and lot/batch No.of test material: 116B2018
- Purity: 96.7% - Key result
- Water solubility:
- 2.78 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 5 - <= 10 d
- Temp.:
- 25.7 °C
- Remarks on result:
- other: pH not measured
- Remarks:
- Unit reported as ng/mL.
- Details on results:
- Average measured PPVE-2 water solubility in individual test vials ranged from 2.55 ng/mL to 3.46 ng/mL (n =3). The intra-day average solubility concentration ranged from 2.68 ng/mL to 2.96 ng/mL (n= 9). The overall average (N=36) was 2.78 ng/mL (RSD = 11%).
- Conclusions:
- Under conditions of this study, the average measured water solubility of PPVE-2 is 2.78 ng/mL (RSD=11%) at 25.7°C.
- Executive summary:
The water solubility of PPVE-2 was determined according to OPPTS 830.7840 “Water Solubility: Column Elution Method; Shake Flask Method”.
Triplicate test vials were prepared by injecting 100 μl of PPVE-2 into the test vials pre-filled with Milli-Q reagent water to zero-headspace. The vials were incubated at approximately 30°C with shaking at 100 rpm for total of 4 time points (5, 6, 7, and 10 days). At the end of each time point, the vials were centrifuged at a setting of 1000 rpm for at least 15 minutes, then allowed to equilibrate for at least 24 hour at 24.9 – 26.3 °C. Triplicate aliquot of 5 mL of the aqueous solution were removed from the test vial and transferred to a separate vial containing 5 mL of MilliQ water, and analyzed using purge and trap gas chromatography/mass spectrometry (GC/MS). The intra-day average solubility concentration ranged from 2.68 – 2.96 ng/mL (N = 9). The overall average (N=36) was 2.78 ng/mL (RSD = 11%).
This is a guideline study conducted under GLP. Therefore, it is considered reliable without restriction and a key study.
Table 1. Summary of PPVE-2 water solubility results (ng/mL) (1)
Sample |
Time point 1 (Five days) |
Time point 2 (Six days) |
Time point 3 (Seven days) |
Time point 4 (Ten days) |
Vial 1 Avg (2) |
2.55 (17%) |
2.59 (9.4%) |
2.62 (2.7%) |
3.46 (7.8%) |
Vial 2 Avg (2) |
3.00 (2.9%) |
2.83 (10%) |
2.72 (5.0%) |
2.81 (3.5%) |
Vial 3 Avg (2) |
2.79 (3.8%) |
2.70 (4.2%) |
2.70 (4.4%) |
2.59 (4.1%) |
Intra-day Average |
2.79 |
2.71 |
2.68 |
2.96 |
Intra-day %RSD |
11 |
8.2 |
4.0 |
14 |
N |
9 |
9 |
9 |
9 |
Inter-day Average |
2.78 |
|
|
|
Inter-day %RSD |
11 (n = 36) |
|
|
|
(1) PPVE-2 Solubility Concentration (ng/mL) using EXTERNAL Standard Quantitation. Results are considered accurate to within the calculated analytical method uncertainty for PPVE-2 of 100±37%.
2) Average of triplicate aliquots, number in parentheses are % RSD of the triplicate aliquots (Intra-vial precision).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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