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EC number: 233-360-4 | CAS number: 10128-55-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 06 to February 08, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 101.7 mg the test item was transferred to 1 L dilution water in a glass bottle containing a magnetic stirrer. The solution was stirred for about 48 hours at room temperature and thereafter was filtered through a 0.22 µm PES filter to remove unsoluble parts of the test item.Samples were taken from fresh and aged test solutions and the control prior to distribution to the test vessels. At the end of the test, samples were taken directly from two representative replicates of the test concentration and control. Analysis of all samples was performed at test end. The water solubility was determined by LC-MS
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from May 31, 2016
- Type of method:
- other: LC-MS
- Water solubility:
- 46.11 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 18.8 °C
- pH:
- >= 8.03 - <= 8.57
- Details on results:
- The measured concentrations at test termination (during 48 h) were within a range of 80 – 120 % of the initial concentrations confirming the stability of the test item throughout the test.
Regression quality
The basic calibration standards covered concentrations from 0.1 µg/L to 10.0 µg/L. As the calculated correlation coefficient (r²) for Lumilux® Yellow CD397 was close to 1 [r² = 0.996397], the applicability of the linear calibration function was accepted.
Method validation
The analytical method for N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]naphthalene-2-sulphonamide has been successfully validated in accordance with the EU guidance document SANCO/3029/99 rev. 4 (11/07/00) on two fortification levels.
Accuracy (recovery)
The mean recovery of each fortification level and the overall mean recovery value is defined by SANCO/3029/99 rev.4 (11/07/00) (recovery 70 – 110% with an RSD < 20%). The mean recoveries and the overall mean recovery values are in the defined range of SANCO/3029/99 rev.4 (11/07/00). The accuracy of the method can be accepted.
Repeatability (precision)
The mean RSDs of 10.4% and 2.2% for LOQ and 10x LOQ as well as the overall mean RSD of 7.9% prove the repeatability of the analytical method for the analyte in aqueous solution.
Specificity and blanks
The LC-MS system used was capable to determine the analyte N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]naphthalene-2-sulphonamide in the worked-up injection-solutions without interference of matrix compounds.
The specificity of the method is shown by an example of an UHPLC-MS/MS chromatogram of untreated fortification sample (blank) in methanol / copper-free water (75:25 v:v). Since there were no detectable respective mass transitions at the retention time of the analyte, the method is accepted as specific. - Conclusions:
- N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]naphthalene-2-sulphonamide has a water solubility of 46.11 µg/L at 18.8 °C.
Reference
Measured concentration of test item
Nominal concentration | 0 h fresh | 48 h aged | Geometric mean measured conc. |
|||||
[mg/L] |
[mg TI/L] |
[µg/L] |
% of nominal |
[µg/L] |
% of nominal |
% of initial |
[µg/L] |
% of nominal |
Control |
Control |
< LOQ * |
- |
< LOQ * |
- |
- |
< LOQ * |
- |
100.0 |
101.7 |
45.38 |
0.05 |
46.86 |
0.05 |
0.05 |
46.11 |
0.05 |
The measured concentration of test item in fresh prepared test solutions at test start was 45.38 µg/L (corresponding to 0.05 % of the nominal concentration). In aged test solution measured concentration of test item was 46.86 µg/L (corresponding to 0.05 % of the nominal concentration). The resulting geometric mean measured concentration of initial and aged test solutions was 46.11 µg/L (0.05 % of nominal)
Description of key information
N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]naphthalene-2-sulphonamide has a water solubility of 46.11 µg/L at 18.8 °C.
Key value for chemical safety assessment
- Water solubility:
- 46.11 µg/L
- at the temperature of:
- 18.8 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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