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Diss Factsheets
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EC number: 215-516-3 | CAS number: 1328-18-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 59805.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974/75
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- EC Number:
- 215-516-3
- EC Name:
- Anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- Cas Number:
- 1328-18-3
- Molecular formula:
- C34H14Br2O2
- IUPAC Name:
- anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- Test material form:
- solid
- Details on test material:
- Vat Blue 19
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5% aqueous solution
- Details on exposure:
- Concentration in vehicle: 1.5 to 35%
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- NA
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: intraperitoneal in mouse
- Mortality:
- No data
- Clinical signs:
- stagger, spastic movements, dyspnea, apathy, paresis of the rear extremities
- Body weight:
- A body weight loss at the beginning of experiment was reported.
- Gross pathology:
- intradominal fluids
Applicant's summary and conclusion
- Conclusions:
- In an acute intraperitoneal toxicity study, the LD50 of the test item was determined to be approximately 250 mg/kg bw in mice.
- Executive summary:
In an acute intraperitoneal toxicity study according to BASF method, mice were given a single oral dose of 1.5 - 35 % suspension of the test item diluted in 0.5% aqueous carboxymethylcellulose and were observed for 7 days.
All animals survived until the end of the study. A body weight loss at the beginning of experiment was reported. Adverse clinical signs of toxicity were observed, such as stagger, spastic movements, dyspnea, apathy, paresis of the rear extremities. Moreover, gross pathological findings were intradominal fluids. Based on the results from this study, the LD50 of the test item was determined to be approximately 250 mg/kg bw in mice.
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