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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 275-062-7 | CAS number: 70955-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.16 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 350 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The study used for deriving this DNEL is an OECD guideline n° 422 study performed in April 2017. Rats were exposure daily by gavage to 0; 50; 150 and 500 mg/kg/day of the substance (Rhodiantal Original IBCH). A NOAEL for reproductive performance (mating, fertility and delivery) was considered to be 50 mg/kg/day based on the prolonged pre-coital and gestation times and the lower fertility and gestation indexes at 500 mg/kg/day, and on the lower number of corpora lutea, implantation sites and pups delivered, and the higher pre- and post-implantation loss from 150 mg/kg/day. This NOAEL was used as a point of departure for the derivation of the DNEL (NOAEL = 50 mg/kg/day).
Route to route extrapolation (modification of the starting point)
Corrected inhalation NAEC = 50 mg/kg/day * 70 / 10 = 350 mg/m3
(70 kg: mean human body weight - 10 m3: respiratory volume light activity for worker 8 hrs)
- AF for differences in duration of exposure:
- 3
- Justification:
- Subacute to sub-chronic extrapolation (ECHA R8 guidance default value).
Sub-chronic study is sufficient to investigate the impact on the reproductive organs and on fertility. - AF for interspecies differences (allometric scaling):
- 4.5
- Justification:
- Study performed on rats (ECHA R8 guidance default value).
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA R8 guidance default value for remaining differences.
- AF for intraspecies differences:
- 5
- Justification:
- ECHA R8 guidance default value for workers.
- AF for remaining uncertainties:
- 2
- Justification:
- The study used is an OECD 422 study (sreening test).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.16 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Since no data regarding the adsorption rate of the substance by dermal route is available, the following hypothesis was assumed:
Oral adsorption rate = dermal adsorption rate
NOAEL (oral) (rat) = 50 mg/kg/day
NOAEL (dermal) (rat) = 50 mg/kg/day
- AF for differences in duration of exposure:
- 3
- Justification:
- Subacute to sub-chronic extrapolation (ECHA default value).
Sub-chronic study is sufficient to investigate the impact on the reproductive organs and on fertility. - AF for interspecies differences (allometric scaling):
- 4.5
- Justification:
- Study performed on rats (ECHA R8 guidance default value).
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA R8 guidance default value for remaining differences.
- AF for intraspecies differences:
- 5
- Justification:
- ECHA R8 guidance default value for workers.
- AF for remaining uncertainties:
- 2
- Justification:
- The study used is an OECD 422 study (sreening test).
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.29 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 175 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Route to route extrapolation (modification of the starting point)
Corrected inhalation NAEC = 50 mg/kg/day * 70 / 20 = 175 mg/m3
(70 kg: mean human body weight - 20 m3: respiratory volum for general population 24 hrs)
- AF for differences in duration of exposure:
- 3
- Justification:
- Subacute to sub-chronic extrapolation (ECHA default value).
Sub-chronic study is sufficient to investigate the impact on the reproductive organs and on fertility. - AF for interspecies differences (allometric scaling):
- 4.5
- Justification:
- Study performed on rats (ECHA R8 guidance default value).
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA R8 guidance default value for remaining differences.
- AF for intraspecies differences:
- 10
- Justification:
- ECHA R8 guidance default value for general population.
- AF for remaining uncertainties:
- 2
- Justification:
- The study used is an OECD 422 study
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.08 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Since no data regarding the adsorption rate of the substance by dermal route is available, the following hypothesis was assumed:
Oral adsorption rate = dermal adsorption rate
NOAEL (oral) (rat) = 50 mg/kg/day
NOAEL (dermal) (rat) = 50 mg/kg/day
- AF for differences in duration of exposure:
- 3
- Justification:
- Sub-acute to sub-chronic extrapolation (ECHA default value).
Sub-chronic study is sufficient to investigate the impact on the reproductive organs and on fertility. - AF for interspecies differences (allometric scaling):
- 4.5
- Justification:
- Study performed on rats (ECHA R8 guidance default value).
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA R8 guidance default value for remaining differences.
- AF for intraspecies differences:
- 10
- Justification:
- ECHA R8 guidance default value for general population.
- AF for remaining uncertainties:
- 2
- Justification:
- The study used is an OECD 422 study.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.08 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
No need to modify the strating point.
- AF for differences in duration of exposure:
- 3
- Justification:
- Sub-acute to sub-chronic extrapolation (ECHA default value).
Sub-chronic study is sufficient to investigate the impact on the reproductive organs and on fertility. - AF for interspecies differences (allometric scaling):
- 4.5
- Justification:
- Study performed on rats (ECHA R8 guidance default value).
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA R8 guidance default value for remaining differences.
- AF for intraspecies differences:
- 10
- Justification:
- ECHA R8 guidance default value for general population.
- AF for remaining uncertainties:
- 2
- Justification:
- The study used is an OECD 422 study.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.