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EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- yes
- Remarks:
- Several hardness measurements (109-140 mg/L as Ca2C03) were recorded outside the targeted range (110-130 mg/L as Ca2C03) for this parameter. This deviation had no effect on the study.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-4 (Fish Early Life-Stage and Aquatic Invertebrate Life-Cycle Studies)
- Deviations:
- yes
- Remarks:
- Several hardness measurements (109-140 mg/L as Ca2C03) were recorded outside the targeted range (110-130 mg/L as Ca2C03) for this parameter. This deviation had no effect on the study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Details on test material:
- Purity: 99.38%
Impurities: Not reported
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- Cold dilution water
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 90 d
Test conditions
- Hardness:
- 109-140 mg/L (as Ca2CO3)
- Test temperature:
- 11.0 to 13.2°C
- pH:
- 6.8 to 7.5
- Dissolved oxygen:
- Between 65 and 101% of saturation
- Nominal and measured concentrations:
- Nominal: 6.3, 12.5, 25, 50, and 100 mg/L
Measured: 7.6, 15, 29, 52, and 95 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 90 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.6 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Key result
- Duration:
- 90 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 15 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Duration:
- 90 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC was 7.6 mg/L based on mean measured concentrations of last day of hatching.
The MATC and LOEC based on the last day of hatching were 11 and 15 mg/L. - Executive summary:
The effect of the test substance on hatching, growth and survival of rainbow trout, Oncorhynchus mykiss, embryos, alevins, and fingerlings was assessed in a flow-through, 90-day early life-stage toxicity test according to the guidelines OECD 210 and EPA OPP 72-4.
Nominal test concentrations were 6.3, 12.5, 25, 50, and 100 mg/L and a water control.
Measured test concentrations were 7.6, 15, 29, 52, and 95 mg/L; less than limit of detection (LOD, 0.11 mg/L) in water control.
Age of test organisms (Unfertilized eggs and sperm) is approximately 22 hours post-fertilization at test start.
A total of 80 embryos were exposed per concentration (20 embryos per embryo cup, 2 cups per replicate, 2 replicates per concentration) at test start. On day 40, after swim-up had begun in the controls, the fingerlings were thinned to a total of 30 fish per concentration (15 fish per replicate, 2 replicates per concentration). Analytical verification of the test substance concentrations was made on test solutions sampled on day 0, once weekly, and on day 90 at test end. Additional samples were submitted or analysis as warranted. Test solutions were supplied to each replicate test chamber by a proportional diluter system at a rate of approximately 1.25 L per hour (approximately five 6-L test solution volume additions per day). Embryos and alevins were held in relative darkness until day 35, and then held under a photoperiod of 16 hours light and 8 hours darkness (which included 30 minutes of transitional light between light and dark intervals) for the remainder of the study. After thinning, the fingerlings were fed newly-hatched brine shrimp (days 40-49) or newly-hatched brine shrimp and trout chow (days 50-89). Test solutions were maintained between 11.0 and 13.2°C (mean 11.8°C). Daily observations were made for assessment of number of dead eggs at hatching, first and last day of hatching, first day of swim-up, survival and abnormalities from hatching to thinning, and survival and abnormalities from thinning to test end. Standard length and blotted wet weight of surviving fingerlings were determined at test end.
The NOEC (No Observable Effect Concentration) for the test substance a 90-day early life-stage toxicity study using rainbow trout, Oncorhynchus mykiss, was 7.6 mg/L based on mean, measured concentrations and last day of hatching. The MATC (Maximum Acceptable Toxicant Concentration) was 11 mg/L, and the LOEC (Lowest Observed Effect Concentration) was 15 mg/L.
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