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Diss Factsheets
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EC number: 229-765-0 | CAS number: 6713-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 May 2017 to 19 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: Each test solution was prepared by mixing test substance with distilled water in a small vial respectively. The test solutions were mixed well and then examined for evidence of phase separation and precipitation
- Key result
- Water solubility:
- > 897.3 g/L
- Conc. based on:
- test mat.
- Temp.:
- 22 °C
- pH:
- 11.63
- Details on results:
- No phase separation was observed. The substance was miscible with water when tested up to 897.3 g/L at 22°C.
- Conclusions:
- The substance was miscible with water when tested up to 897.3 g/L at 22°C.
- Executive summary:
The water solubility of 1-[(2-hydroxyethyl)thio]propan-2-ol was evaluated in accordance with the OECD Testing Guideline 105. A visual assessment was performed showing high values of solubility, which suggested that a shake flask test would not be appropriate as a saturated solution may not be achieved. A full visual test was then carried out to confirm whether the test item is miscible in all proportions in water.
Nine test solutions were prepared by weighing accurately between 1g and 9g of test substance into a small vial and adding between 9g and 1g of distilled water respectively to prepare test solutions between approximately 10% and 90%. The test solutions were mixed well and then examined for evidence of phase separation and precipitation.
The pH of each test solution was measured along with distilled water blank. The temperature at which testing was performed was not specifically recorded. The testing was performed at ambient lab temperature, typically 22°C.
No phase separation was observed. The substance was miscible in all proportions with water. It can be concluded that the water solubility of the substance is > 897.3 g/L at 22°C.
Reference
Description of key information
The water solubility of 1-[(2-hydroxyethyl)thio]propan-2-ol was evaluated in accordance with the OECD Testing Guideline 105. A visual assessment was performed showing high values of solubility, which suggested that a shake flask test would not be appropriate as a saturated solution may not be achieved. A full visual test was then carried out to confirm whether the test item is miscible in all proportions in water.
Nine test solutions were prepared by weighing accurately between 1g and 9g of test substance into a small vial and adding between 9g and 1g of distilled water respectively to prepare test solutions between approximately 10% and 90%. The test solutions were mixed well and then examined for evidence of phase separation and precipitation.
The pH of each test solution was measured along with distilled water blank. The temperature at which testing was performed was not specifically recorded. The testing was performed at ambient lab temperature, typically 22°C.
No phase separation was observed. The substance was miscible in all proportions with water. It can be concluded that the water solubility of the substance is > 897.3 g/L at 22°C.
Key value for chemical safety assessment
- Water solubility:
- 897.3 g/L
- at the temperature of:
- 22 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.