Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-671-7 | CAS number: 1340-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- February to March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Ichthyolic Acid, Sodium Salt (former INCI: sodium shale oil sulfonate) is a surfactant of amphiphilic nature. As a UVCB substance it contains a large variety of organic (thiophene based) sulfonate entities based on a defined shale oil fraction. Due to the extreme complexity of the substance resolution of the molecular structures is not possible. It can be assumed that the substance is largely ionized in water. In a octanol-water mixture emulsion formation is observed with clouding of both phases.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: COUNCIL REGULATION (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 (REACH): A.8. PARTITION COEFFICIENT Appendix I Estimation Method
- Version / remarks:
- 30 May 2008
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Solubility of substances is addressed in chapter 1.4 of the European Pharmacopoeia (9th edition, 2018). The approximate volume of solvent in millilitres per gram of solute is taken as a measure for the extent of solubility. Solubility is checked in such a way that ratios of solvent and solute are prepared in order to facilitate classification of a test substance with regard to the descriptive term (e.g. “practically insoluble” if more than 10000 ml of solvent per gram of solute is needed). As ICHTHYOL PALE (as a trademark substance of Ichthyolic Acid, Sodium Salt) is distinguished by a brownish-black color as pure raw material, it can be visually controlled if a homogenous solution can be achieved or not (e.g. colored sediment in flask).
- GLP compliance:
- yes
- Remarks:
- Quality Control Laboratory in a GMP certified pharmaceutical manufacturer (quality standard comparable to GLP)
- Other quality assurance:
- other: GMP
- Remarks:
- The laboratory is active in quality control of ICHTHYOL substances (entrance inspection, release, stability studies) in a GMP environment
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Ichthyolic acid, sodium salt
- EC Number:
- 215-671-7
- EC Name:
- Ichthyolic acid, sodium salt
- Cas Number:
- 1340-06-3
- IUPAC Name:
- Identification of the UVCB substance by "Chemcial Abstracts Index Name", among others: Ichthyolic Acid, Sodium Salt. No IUPAC name known.
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- ICHTHYOL PALE batch 0041117208Ö3/17
batch from regular production at ÖSTERREICHISCHE ICHTHYOL (registrant's manufactcuring site)
Sample used was taken from bulk material as delivered to ICHTHYOL-GESELLSCHAFT Cordes, Hermanni & Co. (GmbH & Co.) KG for repacking and worldwide distribution.
Based on stability studies („Note for Guidance on Stability Testing of Existing Active Substances and Related Finished Products” (EMEA “CPMP/QWP/122/02, Corr. dated November 2002) no special storage conditions apply. Especially, ICHTHYOL® PALE is not susceptible to water vapour in the ambient air as it is a raw material consisting of up to 50% of water. Under storage conditions at the different storage temperatures a thermodynamic equilibrium develops between liquid and gas phase with saturation vapour pressure of water vapour in the gas phase. The corresponding humidity should be considerably higher than the ones proposed in the above mentioned “Note for Guidance” (e.g. 60% or 65% RH). For this reason, penetration of water from outside is not likely. However, as outwards penetration (inside -> outside) may occur instead, the dry matter of ICHTHYOL® PALE is one of the parameters regularly examined during storage.
For the batch used in solubility testing compliance with specification parameters (including dry matter) is confirmed by a certificate of analysis signed by quality control units of both ÖSTERREICHISCHE ICHTHYOL in Reith bei Seefeld, Austria, and ICHTHYOL-GESELLSCHAFT in Hamburg, Germany.
Study design
- Analytical method:
- other: solubility testing with classification according to the European Pharmacopoeia, 9th edition, 2018, chapter 1.4
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0
- Temp.:
- 20 °C
- pH:
- >= 6 - <= 7.5
Applicant's summary and conclusion
- Conclusions:
- It is not possible to obtain a clear solution of Ichthyolic Acid, Sodium Salt in n-octanol. Even in a concentration of less than 0.1% a colored sediment is observed in the flask. This is in line with the descriptive term "practically insoluble" according to the European Pharmacopoeia. As ICHTHYOL PALE is obtained by sulfonation of a sulfur-rich shale oil fraction with a wide boiling range comprising about 100°C at a pressure of 0.1 hPa, there may be compounds at least partly soluble in n-octanol. However, no coloring of the solvent phase can be detected. Solubility therefore should be less than 0.1 g/l.
On the other hand, ICHTHYOL PALE is soluble in water in all ratios applied (solute:solvent = 3:7, 5:5, 9:1). We, therefore, can assume that ICHTHYOL PALE at least is "freely soluble" in water which is in line with a concentration of more than 900 g/l.
If these solubility limits are taken for an estimation of the partition coefficient we obtain log Pow of less than zero (< 0).
The same result can be obtained when considering the topic from another perspective. ICHTHYOL PALE is a mixture of a sulfonate salt with water (which results as a by-product in the manufacturing process). In fact, about 50% of water can be found besides so-called "dry matter", i.e. ICHTHYOL PALE can be regarded as a 50% solution (corresponding to a solution of about 500 g/l). By evaporation there may appear a ratio of dry matter to water which results in precipitation of compounds belonging to the "dry matter". However, for the purpose of estimation of a partipition coefficient such an information is irrelevant because again a very poor solubility of ICHTHYOL PALE in n-octanol has to be related to very high solubility of ICHTHYOL PALE in water. And again the log Pow is estimated to be below zero.
As the composition of "dry matter" in ICHTHYOL PALE is not available due to the high complexity of it, there is no way for calculation of a partition coefficient. Determination of the partition coefficient by a practical analytical method is not feasible due to the surface activity of ICHTHYOL PALE. However, the estimated partition coefficient of < 0 is in line with what is known about partition coefficients of surfactant with a better known molecular structure (as e.g. sodium laureth sulfates).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.