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EC number: 212-534-3 | CAS number: 824-72-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-04-24 - 2018-05-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phenylphosphonic dichloride
- EC Number:
- 212-534-3
- EC Name:
- Phenylphosphonic dichloride
- Cas Number:
- 824-72-6
- Molecular formula:
- C6H5Cl2OP
- IUPAC Name:
- phenylphosphonic dichloride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Name phenylphosphonic dichloride
Batch no. 201 712 01 - 01
Appearance liquid, clear
Composition phenylphosphonic dichloride: >98%
CAS No. 824-72-6
EINECS-No. 212-534-3
Molecular formula C6H5POCI2
Molecular weight 194.98 g/mol
Purity >98%
Homogenity homogeneous
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Specification
Activated sludge from a biologic sewage treatment plant was used. The chosen plant treats mostly domestic sewage.
Source and Pre-Treatment
Source
The sludge was taken from the activation basin of sewage treatment plant, In den Seewiesen, 67482 Edenkoben.
Date of collection: 26. Apr. 2018, batch no: 20180426.
Pre-Treatment
The sludge was filtrated through a clean cotton cloth, then washed with test medium 2x and resuspended in test medium. It was then aerated until use in the test. Determination of dry matter gave 4320 mg suspended solids/L. - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 79.83 mg/L
- Based on:
- DOC
- Remarks:
- Test 1
- Initial conc.:
- 79.86 mg/L
- Based on:
- DOC
- Remarks:
- Test 2
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- This study was performed in order to evaluate aerobic elimination and degradation poten-tial of phenylphosphonic dichloride in a test for ready biodegradability, using a nominal concentration of 40 mg organic carbon/L.
A solution of the test item in a mineral medium was inoculated and incubated under aero-bic conditions in the dark. The amount of DOC in the test solution due to the inoculum was kept as low as possible compared with the amount of organic carbon due to the test item. Allowance was made for the endogenous activity of the inoculum by running parallel blanks with inoculum but without test item, although the endogenous activity of cells in the presence of a chemical was not exactly matched that in the endogenous control. A positive control was run in parallel to check the operation of the procedures. Degradation was followed by the determination of dissolved organic carbon (DOC) and measurements were taken at sufficiently frequent intervals to allow the identification of the beginning and end of biodegradation. The test lasted for 28 days.
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 3.7
- Sampling time:
- 4 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 1.9
- Sampling time:
- 11 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 2.1
- Sampling time:
- 20 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 2
- Sampling time:
- 28 d
Any other information on results incl. tables
Degradation values in %
Day |
Positive Control 1 |
Positive Control 2 |
Positive Control Mean |
Test 1 |
Test 2 |
Test |
Abiotic Control |
Adsorption Control |
Toxicity Control |
4 |
69.0 |
97.0 |
83.0 |
3.5 |
3.8 |
3.7 |
1.4 |
3.0 |
37.8 |
7 |
97.8 |
95.7 |
96.8 |
4.3 |
3.3 |
3.8 |
4.1 |
1.6 |
50.2 |
11 |
97.6 |
97.3 |
97.5 |
3.5 |
0.3 |
1.9 |
-0.7 |
0.7 |
48.1 |
15 |
97.3 |
98.0 |
97.7 |
-0.9 |
-5.1 |
-3.0 |
-4.3 |
-6.9 |
45.9 |
20 |
97.1 |
98.3 |
97.7 |
3.8 |
0.4 |
2.1 |
2.0 |
-1.6 |
49.6 |
26 |
97.9 |
98.6 |
98.3 |
3.6 |
-0.7 |
1.5 |
-4.3 |
0.3 |
48.8 |
28 |
98.4 |
98.6 |
98.5 |
2.5 |
1.5 |
2.0 |
-5.3 |
3.0 |
50.6 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item phenylphosphonic dichloride is not readily biodegradable following OECD 301A/EU C.4-A. As degradation missed 70% in the course of the test, phenylphosphonic dichloride is considered as not ultimately biodegradable, either.
- Executive summary:
The test item was tested using a nominal concentration of 40 mg organic carbon/L in test medium following OECD 301A and EU-Guideline C.4-A.
Aniline was chosen as positive control.
Activated sludge was used as inoculum (concentration in the test 25.1 mg dry matter/L). The test was left running for 28 days.
All validity criteria were met. Degradation of the positive control was 83 % after 4 days.
The following data were determined for the test itemphenylphosphonic dichloride:
10-day-window: not detected
degradation at the end of 10-day-window none
degradation at the end of the test 2 %
Therefore, the test itemphenylphosphonic dichlorideisnotreadily biodegradablefollowing OECD 301A and EU C.4-A respectively.
Therefore, when applying the 10-day-window, the test itemphenylphosphonic dichlorideis not readily biodegradable following OECD 301A/EU C.4-A. As degradation missed 70% in the course of the test,phenylphosphonic dichlorideis considered as not ultimately biodegradable,either.
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