Adenosine

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 October 2017 - 12 January 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Adenosine

EC Number:

200-389-9

EC Name:

Adenosine

Cas Number:

58-61-7

Molecular formula:

C10H13N5O4

IUPAC Name:

adenosine

impurity 1

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

Test material form:

solid: particulate/powder

Details on test material:

Batch No.: 10004539
Storage at room temperature approx. 20°C

Results and discussion

Boiling point

Key result

Atm. press.:

>= 1 014 - <= 1 016 hPa

Decomposition:

yes

Decomp. temp.:

ca. 250 °C

Remarks on result:

other: No boiling point up to its decomposition starting at a temperature of approx. 250 °C

Any other information on results incl. tables

In the temperature range of 230 – 250 °C, an endothermic effect was observed, which be assigned to the melting of the test item. The endothermic effect was directly followed by an exothermic effect in the temperature range of 250 – 300 °C, with an average decomposition energy of -220 J/g. No further thermal effects were observed up to the test end temperature of 500 °C.

Since no second endothermic effect could be observed up the decomposition of the test item starting at a temperature of approx. 250 °C it can be stated that the test item Adenosine (CAS no. 58-61-7) has no boiling point.

To verify the results of the DSC measurement, two additional measurements with the capillary method (Apparatus: Stuart Melting Point SMP30) were performed in the temperature range of 150 – 350 °C with a heating rate of 10 K/min. The test item changed its colour from white to black starting at a temperature of approx. 260 °C and expands throughout the capillary. Due to this result, the test item has no boiling point before its decomposition starting at a temperature of about 250 °C. 

The detailed results of the DSC-measurements are given in the table in the field 'Overall remarks'.

Applicant's summary and conclusion

Conclusions:

The test item Adenosine (CAS no. 58-61-7) has no boiling point up to its decomposition starting at a temperature of approx. 250 °C at atmospheric pressure (1014 – 1016 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).

Executive summary:

The test item Adenosine (CAS no. 58-61-7) has no boiling point up to its decomposition starting at a temperature of approx. 250 °C at atmospheric pressure (1014 – 1016 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).