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EC number: 270-846-5 | CAS number: 68478-97-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1.
- Deviations:
- yes
- Remarks:
- Due to the severity of the reactions three animals only were used.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether
- EC Number:
- 270-846-5
- EC Name:
- 2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether
- Cas Number:
- 68478-97-7
- Molecular formula:
- C10H23BF3NO2
- IUPAC Name:
- 2-propanamine, compd. with boron trifluoride, reaction products with butyl glycidyl
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of pure material
- Duration of treatment / exposure:
- 24 h exposure period
- Observation period:
- 24 h and 72 h
- Number of animals:
- 3
- Details on study design:
- Testing was performed according to the above reference and is briefly
summarized as follows :
3 rabbits were clipped free of hair. On one side of the animal was the skin abraded.
The sample (0.5 ml ) was then applied directly to the exposed skin and abraded skin of each animal and was covered with gauze squares which were securely taped and wrapped.
At the end of a 24-hour exposure period, the bandages were removed and the sample was washed from the skin.
Dermal reactions, erythema, edema, and necrosis were evaluated at 24 and 72 hours after exposure.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 H
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Clipped skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin
- Irritant / corrosive response data:
- Severe "in deptht' skin damage with necrosis and small capillary hamorrhages was observed in all three animals at the 24 hours reading.
Similar reactions were seen at the 72 hours reading, although there was some reduction in the degree of oedema.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was found to be corrosive in study using Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1. test method with rabbits.
- Executive summary:
Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl etherwas tested for corrosivity using Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1. test method with rabbits. Severe skin corrosion was observed in all three animals at the 24 hours reading. Similar reactions were seen at the 72 hours reading, although there was some reduction in the degree of oedema.
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