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Diss Factsheets
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EC number: 241-300-3 | CAS number: 17265-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: OSPAR Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry. OSPAR Commission 2005. PartA: A Sediment Bioassay Using an Amphipod Corophiumsp.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- Acetone (~ 5 mL)
- Details on sediment and application:
- PREPARATION OF SPIKED SEDIMENT
- Pooling or mixing of different substrates: Natural sediment with organic content of 2.1 % and silt fraction of 68 %.
- Details of spiking: The appropriate amount of test substance was dissolved in ~ 5 mL of acetone. This solution was added to ~ 90 g of predried sediment. After the acetone had dried off in a fume cupboard, the sample was added to ~ 500 g of damp sediment in a plastic bucket.
- Equilibration time: ~ 24 h
- Equilibration conditions: 130 - 150 mL of seawater was added to each buckets and the buckets were shaken (100 rpm).
- Chemical name of vehicle (organic solvent): Acetone
- Evaporation of vehicle before use: Yes
OTHER
- The sediment was homogenized before preparing the test sediment.
- Each test concentration was prepared separately.
- The sediment was split into three beakers, 400 mL of seawater was added to each.
- The beakers were aerated over night in a climate controlled room with 15 °C.
- Test organisms (species):
- Corophium volutator
- Details on test organisms:
- TEST ORGANISM
- Source: Biotix (Dag Altin), Trondheim, Norway
- Details on collection: collected 21.10.2009
- Handling of egg masses and larvae: The organisms were transported by car and airplane to Eurofins on 26.10.09.
- Size (range): amphipods were 5 - 10 mm long.
ACCLIMATION
- Acclimation conditions: Temperature 15.0 - 16.4 °C. - Study type:
- laboratory study
- Test type:
- static
- Water media type:
- saltwater
- Type of sediment:
- natural sediment
- Limit test:
- no
- Duration:
- 10 d
- Exposure phase:
- total exposure duration
- Test temperature:
- 14.4 - 15.8 °C
- pH:
- initial 8.0 - 8.1
- Dissolved oxygen:
- Initial: 92-97 % saturation
After 5 d: 91-98 % saturation
After 10 d: 90-96 % saturation - Salinity:
- 34.4 per mill
- Nominal and measured concentrations:
- - Test concentrations nominal: 58, 99, 181, and 340 mg/kg sediment (dry weight)
- Details on test conditions:
- TEST SYSTEM
- Test container: 600 mL glass container
- Sediment volume: ~200 g
- Overlying water volume: ~400 mL seawater
- Aeration: yes
EXPOSURE REGIME
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 3
- No. of replicates per control / vehicle control: 3/3
OVERLYING WATER CHARACTERISTCS
- Type of water: Natural seawater
- Source of water: tap
- Location: Byfjord
- Description of sampling site: unpolluted site at ~ 80 m depths
SOURCE OF NATURAL SEDIMENT
- Location and description of sampling site: Natural sediment from the same unpolluted site as the amphipod was collected and used for the test.
EFFECT PARAMETERS MEASURED
- Measurement of salinity, oxygen, temperature and pH were done at start, after five and after ten days.
- Mortality: After sieving with a mesh size of 0.5 mm the lethality was registered by visual observation.
VEHICLE CONTROL PERFORMED: yes
TEST CONCENTRATIONS
- Test concentrations: 5.6, 10.3, 18.0 and 32.2 mg/kg sediment (dry weight) - Reference substance (positive control):
- yes
- Remarks:
- Fluoranthene
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- 161 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LC10
- Effect conc.:
- 39 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Dicarboxylic acid:
LC10 10d: 39 mg/kg sediment dw
LC90 10d: >340 mg/kg sediment dw - Results with reference substance (positive control):
- Floranthene:
LC10 10d: 7.3 mg/kg sediment dw
LC50 10d: 12 mg/kg sediment dw
LC90 10d 19.7 mg/kg sediment dw
NOEC 10d 5.6 mg/kg sediment dw
Reference
Description of key information
In a study report on sediment toxicity in marine water on Corophium volutator according to the Guideline of the OSPAR Commission (2005), toxic effects were observed (BASF SE, 2009).
Key value for chemical safety assessment
Additional information
In a study report on sediment toxicity in marine water on Corophium volutator according to the Guideline of the OSPAR Commission (2005), toxic effects were observed (BASF SE, 2009).
In a 10 d toxicity study, Corophium volutator in natural seawater sediment were exposed to sebacic acid, according to the OSPAR Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry (OSPAR Commission 2005) (BASF SE, 2009). Corophium volutator were exposed to nominal concentrations of 0 (control), 58, 99, 181, and 340 mg/kg sediment dw under static conditions. The 10 d LC50, based on the observed mortality, was 161.0 mg/kg sediment dw.
However, according to ECHA guidance R7b effects can be extrapolated from the anion or cation, whichever has the most toxic effect, if no data are available on a salt.
If the effect is related to only one of the ions, the classification of the salt should use the effect concentration multiplied by the salt/ion molecular weight ratio.
The molecular weight ratio between salt and ion is 246 : 202 (1.22)
Based on this correction the LC 10 and LC50 for disodium sebacate in the test with the marine species Corophium volutator.was determined to be 47.6 and 196.4 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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