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Diss Factsheets
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EC number: 485-340-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.-07.04.2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 67/548/EEC
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Test temperature:
- 40 °C
- Details on study design: HPLC method:
- Chromatographie Conditions
Except for the detection wavelength the chromatographic conditions were the same for the
determination of t0, the establishment of the calibration graph and the measurement of the test item.
HPLC equipment: HPLC System Agilent 1100 series: HPLC pump G 1312A, autosampler, G1313A, column oven G1316A, degaser G1322A and UVNis detector
G1315B by Agilent.
Column: Stationary phase: LiChrospher 100 CN 5μm by Duratec (17405-02)
material: stainless steel, dimensions: 250 mm x 0 4.6 mm
column temperature: 40 °C
Mobile Phase: Methanol, cleaned water 50:50 % (v/v), isocratic elution
Flow rate: 1.0 ml/min
lnjection volume: 10 μI
Detection wavelength: 210 nm (dead time marker, calibration substances)
222 nm (test item)
lnjection amounts: Dead time marker: 22.6 μg
Calibration substances: 0.63 - 1.90 μg
Testitem:0.117 μg
The dead time marker was dissolved in methanol and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. The calibration substances were dissolved in methanol and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. The item was dissolved in methanol and diluted 0.1 to 1 in the mobile phase and injected as single sample twice. - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 4.2 dimensionless
- pH:
- 7
- Temp.:
- 40 °C
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- > 4.2 dimensionless
- pH:
- 7
- Temp.:
- 40 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item had an absorption coefficient log Koc >4.20
- Executive summary:
The log Koc value of the substance was determined according to OECD Guideline 121 and European Commission Regulation (67 /548/EEC).The HPLC method is based on the correlation between the adsorption coefficient Koc and the retention of a substance on a reversed phase column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties.The average retention data for test substance were 5.70 (1st measurement) and 5.70 (2nd measurement). The adsorption coefficient of the test item was found to be: log Koc = 4.20.
Reference
Individual Results
Determination of the Dead Time to
Dead time marker |
tr in min 1st. measurement |
tr in min 2nd. measurement |
tr in min Mean |
Formamide |
3.276 |
3.276 |
3.276 |
Calibration Data - 1. Measurement
Calibration substance |
1 inj tr in min |
k |
Log k |
Log Koc |
Acetanilide |
4.003 |
0.22 |
-0.65 |
1.25 |
Phenol |
3.905 |
0.19 |
-0.72 |
1.32 |
Atrazin |
4.436 |
0.35 |
-0.45 |
1.81 |
Monuron |
4.572 |
0.40 |
-0.40 |
1.99 |
Triadimenol |
5.071 |
0.55 |
-0.26 |
2.40 |
Linuron |
5.570 |
0.70 |
-0.15 |
2.59 |
Naphthalin |
6.044 |
0.84 |
-0.07 |
2.75 |
Pyrazophos |
7.011 |
1.14 |
0.06 |
3.65 |
Diclofop-methly |
8.167 |
1.49 |
0.17 |
4.20 |
Regression:logKOc=a+bx logk
Parameters: a = 3.31
b=3.17
r2= 0.9506
log Koc of the Test ltem - 1.Measurement
|
1 inj tr in min |
k |
Log k |
Log Koc |
Test item |
21.863 |
5.67 |
0.75 |
5.70 >4.20 * |
*: beyond log Koc value of the highest calibration substance (Diclofop-methyl)
Calibration Data - 2. Measurement
Calibration substance |
1 inj tr in min |
k |
Log k |
Log Koc |
Acetanilide |
4.002 |
0.22 |
-0.65 |
1.25 |
Phenol |
3.903 |
0.19 |
-0.72 |
1.32 |
Atrazin |
4.433 |
0.35 |
-0.45 |
1.81 |
Monuron |
4.567 |
0.39 |
-0.40 |
1.99 |
Triadimenol |
5.067 |
0.55 |
-0.26 |
2.40 |
Linuron |
5.565 |
0.70 |
-0.16 |
2.59 |
Naphthalin |
6.041 |
0.84 |
-0.07 |
2.75 |
Pyrazophos |
7.010 |
1.14 |
0.06 |
3.65 |
Diclofop-methly |
8.160 |
1.49 |
0.17 |
4.20 |
Regression: :logKOc=a+bx logk
Parameters: a=3.32
b=3.17
r2=0.9506
log Koc of the Test ltem - 2. Measurement
|
1 inj tr in min |
k |
Log k |
Log Koc |
Test item |
21.81 |
5.66 |
0.75 |
5.70 >4.20 * |
log Koc of the Test ltem
|
Log Koc |
1stmeasurement |
5.70 >4.20 |
2ndmeasurement |
5.70 >4.20 |
mean |
5.70 >4.20 |
Description of key information
Key value for chemical safety assessment
Other adsorption coefficients
- Type:
- other: 4.20
- at the temperature of:
- 40 °C
Additional information
The log Koc value of the substance was determined according to OECD Guideline 121 and European Commission Regulation (67 /548/EEC).The HPLC method is based on the correlation between the adsorption coefficient Koc and the retention of a substance on a reversed phase column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties.The average retention data for test substance were 5.70 (1st measurement) and 5.70 (2nd measurement). The adsorption coefficient of the test item was found to be: log Koc = 4.20.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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