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EC number: 233-487-5 | CAS number: 10196-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The exact LD50 was not determined; highest applied dose was 900 mg/kg bw (=1000 µl kg/bw).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- The test substance was applied to the abdominal skin in a dose of 1000 µl/kg bw to 5 male rats for 4 hours. Additionally the test substance was applied in doses of 250, 500 or 1000 µl to the back skin to 5 male rats each for 7 hours. Afterwards the test substance was removed by water and soap and the animals were observed for 7 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,4-trimethyl-1-oxa-4-aza-2-silacyclohexane
- EC Number:
- 233-487-5
- EC Name:
- 2,2,4-trimethyl-1-oxa-4-aza-2-silacyclohexane
- Cas Number:
- 10196-49-3
- Molecular formula:
- C6H15NOSi
- IUPAC Name:
- 2,2,4-trimethyl-1,4,2-oxazasilinane
Constituent 1
- Specific details on test material used for the study:
- Aktivator MO = 2,2,4-trimethyl-1-oxa-4-aza-2-silacyclohexane (0) was used as test substance.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- Four or seven hours.
- Doses:
- 1000 µl/kg bw for 4 hours (1000 µl = 900 mg)
250, 500 or 1000 µl/kg bw for 7 hours (= 225, 450 or 900 mg) - No. of animals per sex per dose:
- 5 male rats per dose
- Control animals:
- no
- Details on study design:
- The licking of the test item was prevented by a cardboard collar.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 900 mg/kg bw
- Based on:
- test mat.
- Mortality:
- With 500 µl/kg bw and 1000 µl kg/bw 1 of 5 aninimals died.
- Clinical signs:
- Decrease of the general condition.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- At a dose of 1000 µl/kg bw for 4 hours (1000 µl = 900 mg) no animals died.
At a dose of 250, 500 or 1000 µl/kg bw for 7 hours (= 225 mg) no animals died.
At a dose of 500 or 1000 µl/kg bw for 7 hours (450 or 900 mg) 1 out of 5 animals died.
The exact LD50 could no be determined. However in each case it is greater than 900 mg/kg bw (=1000 µl kg/bw). - Executive summary:
The test substance was applied to the abdominal skin in a dose of 1000 µl/kg bw to 5 male rats for 4 hours. Additionally the test substance was applied in doses of 250, 500 or 1000 µl to the back skin to 5 male rats each for 7 hours. Afterwards the test substance was removed by water and soap and the animals were observed for 7 days. At a dose of 500 or 1000 µl/kg bw for 7 hours (450 or 900 mg) 1 out of 5 animals died. Therefore the LD50 is greatr than 1000 µl/kg bw (900 mg/kg bw). However the exact LD50 was not determined in the study. According to CLP classification criteria (Regulation (EC) No 1272/2008) the study cannot be used for classification.
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