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EC number: 238-339-3 | CAS number: 14367-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male Royal Hart Wistar rats using test chemical.50% mortality was observed at dose 130 mg/kg bw. Hence,LD50 value was considered to be 130 mg/kg bw,when rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in six groups of five Male albino rats of the Charles River strain using test chemical at dose level of 100 ,215 ,464 ,1000 ,2150 and 4640 mg/kg bw.50% mortality was observed at dose 171 mg/kg bw (95% CI Limits:126-233 mg/kg bw).The animals were observed for mortality and pharmacotoxic signs at the following intervals: continuously for 5 hours, at 24 hours, and once daily thereafter for 13 days.Necropsies were performed on those animals which succumbed during the observation period. Clinical signs likepulse rate increase without fall in Bp, Slight dyspnea, salivation, ataxia, moderate hypoactivity ,slight sedation, tremors , clonic convulsions were observed at different doses.In necropsy findings,congestion of lungs , stomach and small intestine,edema of lungs,petechiae in the stomach,a clear fluid in the thoracic cavity,hemorrhages in the stomach were observed at different doses.Hence,LD50 value was considered to be 171 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)and it’s structurally similar read across substance, it can be concluded that LD50 value is between 50-300 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)can be classified as “Category III” for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5) is toxic in the dose range of 130-171 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute oral toxicity studies as-
1.and 2. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents - GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: N-ethyl-p-methoxy-α-methylphenethylamine
- IUPAC name: N-ethyl-1-(4-methoxyphenyl)propan-2-amine
- Molecular formula: C12H19NO
- Molecular weight: 193.2881 g/mole
- Smiles : CCNC(C)Cc1ccc(OC)cc1
- Inchl: 1S/C12H19NO/c1-4-13-10(2)9-11-5-7-12(14-3)8-6-11/h5-8,10,13H,4,9H2,1-3H3
- Substance type: Organic
- Physical state: Liquid (Colorless to pale yellow) - Species:
- rat
- Strain:
- other: 1.Royal Hart Wistar 2.Albino Charles River
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 1.Details on test animal
TEST ANIMALS
- Weight at study initiation:136-160 g
- Housing:animals were placed in 7 x 7 x 14 in wire cages.
2.Details on test animal
TEST ANIMALS
- Weight at study initiation:158-328 g
- Fasting period before study: Food was withheld from all of the rats for 16 hours prior to the administration of the compound.
- Housing:The animals were group-housed by dosage level in metal cages suspended above the droppings with food and water available ad libitum.
- Diet (e.g. ad libitum):food was provided ad libitum
- Water (e.g. ad libitum): water was provided ad libitum - Route of administration:
- other: 1.oral: unspecified 2.oral: gavage
- Vehicle:
- other: 1.not specified 2.methylcellulose
- Details on oral exposure:
- 1.No data available
2.Details on exposure
VEHICLE
- Concentration in vehicle: 100 ,215 ,464 ,1000 ,2150 and 4640 mg/kg bw
- Amount of vehicle (if gavage):1.0 ml/100 g
- Justification for choice of vehicle: Test chemical was soluble in vehicle.
MAXIMUM DOSE VOLUME APPLIED:4640 mg/kg bw
DOSAGE PREPARATION (if unusual): The compound was orally administered in dilution in a 0.5 per cent aqueous dispersion of methylcellulose (Methocel).Each dosage level was individually prepared in a concentration which enabled the delivery of a constant volume of 1.0 ml/100 g. - Doses:
- 1. 130 mg/kg bw
2.100 ,215 ,464 ,1000 ,2150 and 4640 mg/kg bw - No. of animals per sex per dose:
- 1.Total:20 animals
2.Total:30 animals
100 mg/kg bw: 5 males
215 mg/kg bw: 5 males
464 mg/kg bw: 5 males
1000 mg/kg bw: 5 males
2150 mg/kg bw: 5 males
4640 mg/kg bw: 5 males - Control animals:
- not specified
- Details on study design:
- 1.No data available
2.Details on study design
- Duration of observation period following administration: 13 days
- Frequency of observations: The animals were observed for mortality and pharmacotoxic signs at the following intervals: continuously for 5 hours, at 24 hours, and once daily thereafter for 13 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- 1.The LD50 values were obtained 72 hr post -administration of test chemical using 20 rats and estimated by Probit analysis.
2.No data available - Preliminary study:
- No data available
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 130 - 171
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 1.50% mortality was observed at dose 130 mg/kg bw in treated rats
2.50% mortality was observed at dose 171 mg/kg bw - Clinical signs:
- 1.No data available
2.I. pharmacotoxic Signs and Necropsy Findings:
a. 100 mg/kg :
Within 30 minutes following compound administration slightly increased cardiac and respiratory rates were observed. Slight dyspnea, salivation, and ataxia were also observed. These signs continued through the first hour of observation. One-to-three hours following oral intubation of test chemical, the slight salivation and ataxia continued accompanied by slight piloerection and slight sedation.Other signs noted previously were absent at this time. Three-to-five hoursafter administration a decrease in cardiac rate was noted accompanied by slight dyspnea, moderate hypoactivity and slight sedation. At 24 hours all of the animals in this group had returned to normal and remained so for the balance of the 14-day observation period.
b. 215 mg/kg:
Those signs noted at 100 mg/kg were also observed at this Level, accompanied by tremors and clonic convulsions within 30 minutes following oral administration. These signs continued during the first hour. One rat succumbed during the first 30 minutes, 2 rats at one hour, and a 4th rat at 2 hours. At 3 hours, the one animal. Remaining exhibited dyspnea, salivation, and ataxia.
c. 464. 1000, 2150, and 4640 mg/kg bw:
All of the animals at those dosage levels succumbed within 60 minutes following oral intubation of test chemical and exhibited those signs noted at 100 and 215 mg/kg prior to death. - Body weight:
- 1.No data available
2.No data available - Gross pathology:
- 1.No data available
2.At dose 215 mg/g bw, Four-of-four animals which succumbed exhibited congestion and/or edema of the lungs. One-of-four showed mild congestion of the stomach, petechiae in the stomach and a clear fluid in the thoracic cavity.
At 464 mg/kg edema of the lungs, congestion of the lungs,congestion of the stomach and small intestine and hemorrhages in the stomach were observed at necropsy. These signs were also observed at the 1000, 2150 and 4640 mg/kg dosage levels. One animal in the 2150 mg/kg group also exhibited 2-3 mm. hemorrhages in the lung. - Other findings:
- 1.No data available
2.No data available - Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5) is toxic in the dose range of >300-526 mg/kg bw.
- Executive summary:
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male Royal Hart Wistar rats using test chemical.50% mortality was observed at dose 130 mg/kg bw. Hence,LD50 value was considered to be 130 mg/kg bw,when rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in six groups of five Male albino rats of the Charles River strain using test chemical at dose level of 100 ,215 ,464 ,1000 ,2150 and 4640 mg/kg bw.50% mortality was observed at dose 171 mg/kg bw (95% CI Limits:126-233 mg/kg bw).The animals were observed for mortality and pharmacotoxic signs at the following intervals: continuously for 5 hours, at 24 hours, and once daily thereafter for 13 days.Necropsies were performed on those animals which succumbed during the observation period. Clinical signs likepulse rate increase without fall in Bp, Slight dyspnea, salivation, ataxia, moderate hypoactivity ,slight sedation, tremors , clonic convulsions were observed at different doses.In necropsy findings,congestion of lungs , stomach and small intestine,edema of lungs,petechiae in the stomach,a clear fluid in the thoracic cavity,hemorrhages in the stomach were observed at different doses.Hence,LD50 value was considered to be 171 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)and it’s structurally similar read across substance, it can be concluded that LD50 value is between 50-300 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)can be classified as “Category III” for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5) is toxic in the dose range of 130-171mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 171 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5).The studies are as mentioned below:
1.Acute oral toxicity study was performed in male Royal Hart Wistar rats using test chemical.50% mortality was observed at dose 130 mg/kg bw. Hence,LD50 value was considered to be 130 mg/kg bw,when rats were treated with test chemical orally.
2.Acute oral toxicity study was performed in six groups of five Male albino rats of the Charles River strain using test chemical at dose level of 100 ,215 ,464 ,1000 ,2150 and 4640 mg/kg bw.50% mortality was observed at dose 171 mg/kg bw (95% CI Limits:126-233 mg/kg bw).The animals were observed for mortality and pharmacotoxic signs at the following intervals: continuously for 5 hours, at 24 hours, and once daily thereafter for 13 days.Necropsies were performed on those animals which succumbed during the observation period. Clinical signs likepulse rate increase without fall in Bp, Slight dyspnea, salivation, ataxia, moderate hypoactivity ,slight sedation, tremors , clonic convulsions were observed at different doses.In necropsy findings,congestion of lungs , stomach and small intestine,edema of lungs,petechiae in the stomach,a clear fluid in the thoracic cavity,hemorrhages in the stomach were observed at different doses.Hence,LD50 value was considered to be 171 mg/kg bw,when rats were treated with test chemical orally.
Thus, based on the above summarised studies,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)and it’s structurally similar read across substance, it can be concluded that LD50 value is between 50-300 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)can be classified as “Category III” for acute oral toxicity.Hence,based on the data available for the structurally similar read across, test chemical N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5) is toxic in the dose range of 130-171mg/kg bw.
Justification for classification or non-classification
Based on the above experimental studies on N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)and it’s structurally similar read across substances, it can be concluded that LD50 value is between 50-300 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,N-ethyl-p-methoxy-α-methylphenethylamine (14367-46-5)can be classified as “Category III” for acute oral toxicity.
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