Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-535-3 | CAS number: 617-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No measured reproductive toxicity data are available for the registration substance therefore this endpoint is filled by read-across from data on the structural analogue, tetramethylsilane (CAS 75-76-3).
In the key repeated dose inhalation study conducted according to OECD 422 study and in compliance with GLP (Dow Corning Corporation, 2005), whole body exposure of rats to tetramethylsilane did not result in any adverse effects on reproductive parameters that could be attributed to treatment. Therefore, the NOAEC for reproductive toxicity was considered to be at least 5000 ppm (the highest concentration tested), which is equivalent to approximately 24000 mg/m³.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 24 000 mg/m³
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
There are no reproductive toxicity data on triethylsilane via any route of exposure. Therefore data on the structurally similar substance tetramethylsilane (CAS 75-76-3) have been read across for toxicity to reproduction.
The key 28-day combined repeated dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 (1996) and in compliance with GLP (Dow Corning Corporation, 2005). Groups of 10 male and 10 female Sprague-Dawley rats were exposed by whole-body inhalation to vapour at 0, 200, 1000 and 5000 ppm for six hours a day, seven days a week for up to 46 consecutive days. Males and toxicity group females were treated for 28 and 29 days respectively. Reproductive group females were treated for 14 days prior to the mating period, during the mating period then up to and including gestation day 19. There were no adverse effects on reproductive toxicity endpoints at the highest dose tested, 5000 ppm (ca. 24000 mg/m³). No effects on sperm or reproductive parameters were observed.
Read-across hypothesis
The read across hypothesis is that triethylsilane and tetramethylsilane are both hydrolytically stable, and are structurally similar with similar physicochemical properties. Acute toxicity data available for triethylsilane, and repeated dose toxicity data available for tetramethylsilane and the methyl analogue of the registered substance, trimethylsilane (CAS 993-07-7) show similar lack of systemic toxicity.
See Section 'repeated dose toxicity' for further justification of the read-across.
Effects on developmental toxicity
Description of key information
No measured developmental toxicity data are available for the registration substance therefore this endpoint is filled by read-across from data on the structural analogue, tetramethylsilane (CAS 75-76-3).
In the key repeated dose inhalation study conducted according to OECD 422 study and in compliance with GLP (Dow Corning Corporation, 2005), whole body exposure of rats to tetramethylsilane did not result in any adverse effects on developmental parameters that could be attributed to treatment. Therefore, the NOAEC for developmental toxicity was considered to be at least 5000 ppm (the highest concentration tested), which is equivalent to approximately 24000 mg/m³.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 24 000 mg/m³
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
There are no developmental toxicity data on triethylsilane via any route of exposure. Therefore data on the structurally similar substance tetramethylsilane (CAS 75-76-3) have been read across for developmental toxicity.
The key 28-day combined repeated dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 (1996) and in compliance with GLP (Dow Corning Corporation, 2005). Groups of 10 male and 10 female Sprague-Dawley rats were exposed by whole-body inhalation to vapour at 0, 200, 1000 and 5000 ppm for six hours a day, seven days a week for up to 46 consecutive days. Males and toxicity group females were treated for 28 and 29 days respectively. Reproductive group females were treated for 14 days prior to the mating period, during the mating period then up to and including gestation day 19.
There were no adverse effects on developmental toxicity endpoints at the highest dose tested, 5000 ppm (ca. 24000 mg/m³). No effects on pup body weights or pup survival were observed.
Read-across hypothesis
The read across hypothesis is that triethylsilane and tetramethylsilane are both hydrolytically stable, and are structurally similar with similar physicochemical properties. Acute toxicity data available for triethylsilane, and repeated dose toxicity data available for tetramethylsilane and the methyl analogue of the registered substance, trimethylsilane (CAS 993-07-7) show similar lack of systemic toxicity.
See Section 'repeated dose toxicity' for further justification of the read-across.
Justification for classification or non-classification
Based on the available data on tetramethylsilane, triethylsilane does not require classification for reproductive toxicity according to Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.